Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases.

Science China. Life Sciences
Guan YangWenkai Ren

Abstract

Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells. Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate. Some examples of a glutamine metabolism-dependent modulation of the development and progression of several Th17 Treg cell-associated diseases are provided afterward. This review will provide a comprehensive understanding of the importance of glutamine metabolism in the fate of Th17 Treg cell differentiation.

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Citations

Aug 31, 2021·The Kaohsiung Journal of Medical Sciences·Jing-Guo MaLin Zha
Sep 8, 2021·Frontiers in Nutrition·Dongming YuShuai Chen
Nov 9, 2021·Frontiers in Immunology·Hao WangWenkai Ren

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