PMID: 708390Aug 15, 1978Paper

Glutamine metabolism in the kidney during induction of, and recovery from, metabolic acidosis in the rat

The Biochemical Journal
D M Parry, J T Brosnan

Abstract

Experiments were carried out on rats to evaluate the possible regulatory roles of renal glutaminase activity, mitochondrial permeability to glutamine, phosphoenolpyruvate carboxykinase activity and systemic acid-base changes in the control of renal ammonia (NH(3) plus NH(4) (+)) production. Acidosis was induced by drinking NH(4)Cl solution ad libitum. A pronounced metabolic acidosis without respiratory compensation [pH=7.25; HCO(3) (-)=16.9mequiv./litre; pCO(2)=40.7mmHg (5.41kPa)] was evident for the first 2 days, but thereafter acid-base status returned towards normal. This improvement in acid-base status was accompanied by the attainment of maximal rates of ammonia excretion (onset phase) after about 2 days. A steady rate of ammonia excretion was then maintained (plateau phase) until the rats were supplied with tap water in place of the NH(4)Cl solution, whereupon pCO(2) and HCO(3) (-) became elevated [55.4mmHg (7.37kPa) and 35.5mequiv./litre] and renal ammonia excretion returned to control values within 1 day (recovery phase). Renal arteriovenous differences for glutamine always paralleled rates of ammonia excretion. Phosphate-dependent glutaminase and phosphoenolpyruvate carboxykinase activities and the rate of glutamine me...Continue Reading

Citations

Jul 1, 1983·Clinics in Endocrinology and Metabolism·D G Johnston, K G Alberti
Mar 1, 1985·Pflügers Archiv : European journal of physiology·H NonoguchiH Endou
Feb 3, 2017·Physiological Reviews·I David Weiner, Jill W Verlander
Jan 1, 1980·European Journal of Applied Physiology and Occupational Physiology·T C Welbourne
Jan 6, 2009·American Journal of Veterinary Research·Meredyth L JonesCarla L Goad
Jun 19, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chirag PatelRonaldo P Ferraris
Sep 5, 2001·The Journal of Nutrition·N P Curthoys
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Anne M KarinchWiley W Souba
Jun 15, 2017·BioMed Research International·Friederike RoehrbornJohanna K Teloh
Sep 7, 2006·American Journal of Physiology. Renal Physiology·Anne M KarinchWiley W Souba

Related Concepts

Anion Gap
Metabolic Acidosis
Acids
Ammonia
Phosphate-Activated Glutaminase
D-Glutamine
Kidney
Mitochondria
Oxygen Consumption

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