Glutamine stimulates mTORC1 independent of the cell content of essential amino acids

Amino Acids
Martina ChiuO Bussolati

Abstract

Glutamine and leucine are important mTORC1 modulators, although their roles are not precisely defined. In HepG2 and HeLa cells glutamine-free incubation lowers mTORC1 activity, although cell leucine is not decreased. mTORC1 activity, suppressed by amino acid-free incubation, is completely rescued only if essential amino acids (EAA) and glutamine are simultaneously restored, although cell leucine is higher in the absence than in the presence of glutamine. Thus, glutamine stimulates mTORC1 independent of cell leucine, suggesting the existence of two distinct stimulatory signals from either glutamine or EAA.

References

Nov 1, 1990·Journal of Cellular Physiology·B FengS R Max
Jun 9, 2001·Molecular Membrane Biology·O BussolatiG C Gazzola
Aug 3, 2002·European Journal of Biochemistry·Ulrike KrauseLouis Hue
Nov 30, 2004·Biochemical and Biophysical Research Communications·Tohru NakajoYoshio Naomoto
Apr 20, 2005·Placenta·H Y WenY Xia
Jul 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bianca Maria RotoliOvidio Bussolati
Feb 9, 2007·The Journal of Biological Chemistry·Catherine E GleasonMorris J Birnbaum
May 24, 2008·Science·Yasemin SancakDavid M Sabatini
Jul 25, 2008·Journal of the American Society of Nephrology : JASN·Kate EvansAlan Bevington
Sep 4, 2008·American Journal of Physiology. Endocrinology and Metabolism·Joseph AvruchNing Dai
Jan 16, 2009·Biochemical Society Transactions·Yasemin Sancak, David M Sabatini
Jan 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Harinder S Hundal, Peter M Taylor
Apr 3, 2009·Nature Reviews. Molecular Cell Biology·Xiaoju Max Ma, John Blenis
Jul 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Fiona E BairdPeter M Taylor
Sep 16, 2010·American Journal of Physiology. Endocrinology and Metabolism·Caroline Bauchart-ThevretDouglas G Burrin
Oct 23, 2010·Molecular Cell·Shomit SenguptaDavid M Sabatini
Dec 9, 2010·Journal of Molecular Cell Biology·Xuemin Wang, Christopher G Proud
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini

❮ Previous
Next ❯

Citations

May 8, 2014·BioMed Research International·Zhuo WangXian Wang
Jan 24, 2015·Biochemical and Biophysical Research Communications·Natalia S RozasPramod K Dash
Jan 6, 2017·Expert Opinion on Therapeutic Targets·Nicola GiulianiOvidio Bussolati
May 19, 2017·Amino Acids·Martina ChiuOvidio Bussolati
Jan 13, 2018·Cancers·Mathieu PaquetteArnim Pause
Jul 11, 2018·Biotechnology and Bioengineering·Darren GeogheganDavid C James
Nov 29, 2013·The American Journal of Clinical Nutrition·Peter M Taylor
Jul 10, 2020·Cell·Mehdi BouhaddouNevan J Krogan
May 1, 2021·Frontiers in Molecular Biosciences·Stephen J FairweatherStefan Bröer
Nov 20, 2021·Frontiers in Oncology·Keiichiro OkudaYoshito Itoh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.