PMID: 16517950Mar 7, 2006Paper

Glutamine supplementation increases postprandial energy expenditure and fat oxidation in humans

JPEN. Journal of Parenteral and Enteral Nutrition
Soh IwashitaP J Flakoll

Abstract

Glutamine interacts with insulin-mediated glucose disposal, which is a component of the increase in energy expenditure (EE) after a meal. The study aim was to examine if glutamine supplementation alters postmeal nutrient oxidation. Ten healthy young adults consumed a mixed meal (6.5 kcal/kg, 14%:22%:64% = protein:fat:carbohydrate) containing either glutamine (GLN:1.05 kcal/kg) or an isocaloric amino acid mixture (alanine: glycine:serine = 2:1:0.5; CON). GLN and CON treatments were administered on separate days in random order for each subject. EE, nonprotein respiratory quotient (RQ), and fat and carbohydrate oxidation rates were assessed using indirect calorimetry for 30 minutes before and for 360 minutes after meal ingestion. Premeal EE and RQ were similar between treatments. The increase in EE above basal during both early (0-180 minutes) and late (180-360 minutes) postmeal phases was greater in GLN than in CON (p < .05), resulting in postmeal EE being 49% greater during the total postmeal phase (p < .05). Net change of carbohydrate oxidation was 38% higher during the early phase with GLN (p < .05), whereas it was 71% lower during the later phase (p < .05). GLN enhanced fat oxidation by approximately 42 kcal compared with CO...Continue Reading

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Citations

Aug 25, 2012·The British Journal of Nutrition·Christopher P F Marinangeli, Peter J H Jones
Oct 26, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sherif AwadDileep N Lobo
Jan 18, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C J RebelloJ W Finley
Aug 27, 2014·Nutrition Research·Amanda J EslingerRaylene A Reimer
May 12, 2017·Journal of Proteome Research·Renata G DuftCláudia R Cavaglieri
Dec 3, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Adela KrajcovaFrantisek Duska
Feb 6, 2010·Critical Care Medicine·Adam LightfootRichard D Griffiths
Jun 4, 2008·Critical Care Medicine·Richard D Griffiths
Sep 22, 2007·Critical Care Medicine·Thomas BongersAnne McArdle
Feb 28, 2019·Acta Veterinaria Scandinavica·Josefin SöderSara Wernersson
Oct 30, 2020·American Journal of Lifestyle Medicine·Patricia K LukusAlison M Duncan

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