PMID: 8951436Nov 1, 1996Paper

Glutamine synthetase and glutamate metabolism in the guinea pig cochlea

Hearing Research
M EybalinN Renard

Abstract

Glutamate is thought to act as a neurotransmitter of the sensory hair cells of the organ of Corti. Glutamine synthetase could be involved in a type of glutamate-glutamine cycle in the cochlea which could clear glutamate off the synaptic cleft and replenish the hair cell glutamate neurotransmitter store. Using both light and electron microscopic immunocytochemistry to localize this enzyme in the guinea pig cochlea, we have observed immunoreactive satellite glial cells surrounding parvalbumin-immunoreactive primary auditory neurons in the spiral ganglion. Glutamine synthetase was also detected in Schwann cells of the osseous spiral lamina which form the myelin sheath of nerve fibers. On the contrary, no immunoreactivity could be observed in the cochlear nerve and in the organ of Corti, although this organ contains structures able to take up glutamate. Although they confirm earlier works involving glutamine synthetase in the conversion of L-[3H]glutamate taken up by glial cells, our results suggest that the cochlear glutamate-glutamine cycle is not primarily involved in the recycling and replenishment of hair cell neurotransmitter glutamate. Alternatively, it is proposed that glutamine synthetase functions to limit the perilymphat...Continue Reading

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Citations

Mar 15, 2011·The Journal of Membrane Biology·Ioana AlesutanFlorian Lang
Jun 6, 2003·Brain Research Bulletin·Yehoash Raphael, Richard A Altschuler
Sep 2, 2003·Hearing Research·Birgit MazurekJohann Gross
Dec 3, 2008·Human Molecular Genetics·Rick A FriedmanGuy Van Camp
Feb 2, 2013·Hearing Research·Fuxin Shi, Albert S B Edge
Jul 31, 2012·Hearing Research·Tomohiro OguchiOle Petter Ottersen
Jun 27, 2012·Molecular Aspects of Medicine·Andreas EckhardHubert Löwenheim
Oct 5, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Elizabeth J MullinJerome A Roth
Jan 24, 1998·Experimental Neurology·W R PuckettR P Bunge
Feb 1, 2006·Environmental Toxicology and Pharmacology·Sandra CoeckeThomas Hartung
Aug 16, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Grzegorz SulkowskiUrszula Rafałowska
Nov 5, 2014·Developmental Neurobiology·Elisabeth J PechrigglHelga Fritsch
Aug 26, 2010·Acta Oto-laryngologica·Yukihide MaedaKazunori Nishizaki
Jul 14, 2000·Acta Oto-laryngologica·L NordangM Anniko
Jun 29, 2012·Audiology & Neuro-otology·J AttiasA Fattal-Valevski
Dec 22, 2016·International Journal of Molecular Sciences·Karina ChibowskaDariusz Chlubek
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May 28, 2020·Pharmacological Reports : PR·Samira EghbaliferizAmirhossein Sahebkar
Feb 10, 2021·Developmental Neurobiology·David C KohrmanGabriel Corfas
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Mingxuan WuHuawei Li
May 24, 2011·Auris, Nasus, Larynx·Yasue UchidaHiroshi Shimokata

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