PMID: 2463Jan 1, 1975

Glutamine synthetase, glutaminase and phosphodiesterase activities in brain under hypoxia: in vitro effect of cortisol, GABA and serotonin on glutamine synthetase

Environmental Physiology & Biochemistry
V P ChandrasekaranT A Venkitasubramanian

Abstract

The effect of hypobaric hypoxia on the activities of glutamine synthetase, glutaminase and cyclic 3'5' AMP phosphodiesterase in rat brain was studied after exposure to 25,000' for 6 h. Glutamine synthetase activity was increased in all the regions of brain studied, and addition of gamma amino butyric acid, serotonin and cortisol in vitro produced a differential response. Glutaminase activity decreased in the whole brain. Cyclic 3'5' AMP phosphodiesterase activity decreased in cerebellum, medulla, hypothalamus and pituitary showing an accumulation of cyclic 3'5' AMP in these regions. The results suggest that glutamine synthesis and degradation are regulated in the central nervous system by cyclic AMP and cortisol: Gamma aminoburyric acid and other compounds can modulate the activity of glutamine synthetase and glutaminase.

Related Concepts

Aminobutyrates
Anoxemia
Brain
Cerebellum
Insula of Reil
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Phosphate-Activated Glutaminase
Glutamate-Ammonia Ligase
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Medulla Oblongata

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