Glutamine Synthetase: Localization Dictates Outcome

Genes
Alessandra Castegna, Alessio Menga

Abstract

Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to glutamate. In the circulatory system, glutamine carries ammonia from muscle and brain to the kidney and liver. In brain reduction of GS activity has been suggested as a mechanism mediating neurotoxicity in neurodegenerative disorders. In cancer, the delicate balance between glutamine synthesis and catabolism is a critical event. In vitro evidence, confirmed in vivo in some cases, suggests that reduced GS activity in cancer cells associates with a more invasive and aggressive phenotype. However, GS is known to be highly expressed in cells of the tumor microenvironment, such as fibroblasts, adipocytes and immune cells, and their ability to synthesize glutamine is responsible for the acquisition of protumoral phenotypes. This has opened a new window into the complex scenario of the tumor microenvironment, in which the balance of glutamine consumption versus glutamine synthesis influences cellular function. Since GS expression responds to glutamine starvation, a lower glutamine synthesizing power due to the absence of GS in cancer cells might apply a metabolic pressure on stromal cells. ...Continue Reading

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D SmithW R Markesbery
Jan 10, 1998·The Biochemical Journal·C D ListromN M Allewell
Aug 28, 1998·Journal of Neural Transmission·F J Jiménez-JiménezM C Martínez-Para
Feb 23, 1999·Kidney International·M StumvollJ Gerich
Mar 10, 2000·Biochimica Et Biophysica Acta·D EisenbergS H Rotstein
Apr 14, 2000·Brain Research. Molecular Brain Research·F López-RedondoS Kohsaka
May 12, 2001·Mechanisms of Ageing and Development·D A Butterfield, J Kanski
Aug 31, 2001·Microscopy Research and Technique·P RosenstielH Wilms
Nov 8, 2001·American Journal of Physiology. Cell Physiology·A C RimaniolG Gras
May 29, 2003·Journal of Neuropathology and Experimental Neurology·Anne Valérie Vallat-DecouvelaereFrançoise Gray
Jun 6, 2003·Brain Research·Ana Isabel DuarteCatarina Resende de Oliveira
Sep 3, 2003·Journal of Neurochemistry·D Allan ButterfieldAlessandra Castegna
Sep 1, 1959·The Journal of Clinical Investigation·M WALSER, L J BODENLOS
Nov 13, 2004·Journal of Neuropathology and Experimental Neurology·Fabrice ChrétienGabriel Gras
Jun 1, 2005·Neurochemistry International·Arthur J L Cooper, Barry R Freed
Nov 4, 2005·The New England Journal of Medicine·Johannes HäberleHans G Koch
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ellen M van BeekTimo K van den Berg
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
Jun 22, 2006·Journal of Neurochemistry·Lasse K BakHelle S Waagepetersen
Jun 30, 2006·Glia·Cathie LeoneGabriel Gras
Aug 17, 2006·Journal of Leukocyte Biology·Gabriel GrasCathie Leone
Aug 24, 2006·The European Journal of Neuroscience·Mikael PerssonLars Rönnbäck
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Dieter Häussinger, Freimut Schliess
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jul 3, 2009·The American Journal of Clinical Nutrition·Richard A Hawkins
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erikka L CarrKenneth A Frauwirth
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Saul W BrusilowArthur J L Cooper
Feb 15, 2012·Current Alzheimer Research·Suzanne M de la Monte

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Citations

Oct 6, 2018·Plant Signaling & Behavior·Kazi Khayrul Bashar
Feb 12, 2019·Annual Review of Physiology·Xuri LiPeter Carmeliet
Oct 17, 2019·Cold Spring Harbor Perspectives in Medicine·Nina C FlerinMassimiliano Mazzone
May 20, 2020·Frontiers in Oncology·Marina SerraAlessio Menga
Apr 25, 2020·International Journal of Molecular Sciences·Yunuen Ortiz-PedrazaMarcela Lizano
Apr 30, 2020·Scientific Reports·Britta TjadenAlexander Schramm
Oct 2, 2019·Cancer Letters·José M MatésJavier Márquez
Jul 3, 2021·International Journal of Molecular Sciences·Christopher L McGinityDavid A Wink

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xenograft
acetylation

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