PMID: 10812198May 17, 2000Paper

Glutamine transport in brain mitochondria

Neurochemistry International
E KvammeI A Torgner

Abstract

Gln is transported into rat brain synaptic and non-synaptic mitochondria by a protein catalyzed process. The uptake is significantly higher in synaptic than in non-synaptic mitochondria. The transport is inhibited by the amino acids Glu, Asn and Asp, and by the TCA cycle intermediates succinate, malate and 2-OG. The inhibition by 2-OG is counteracted by AOA and is therefore assumed to be due to transamination of 2-OG, whereby Glu is formed. This presumes that Glu also binds to an inhibitory site on the matrix face of the inner membrane. The transport is complex and cannot be explained by the simple uniport mechanism which has been proposed for renal (Schoolwerth and LaNoue, 1985), and liver mitochondria (Soboll et al., 1991). Thus, Gln transport is stimulated by respiration and by the proton electrochemical gradient. Since it is indicated that both the neutral Gln zwitterion and the Gln anion are transported, there are probably different uptake mechanisms, but not necessarily different carriers. Gln may be transported by an electroneutral mechanism as a proton compensated anion, as well as electrophoretically as a zwitterion with a proton, and probably also by diffusion as a zwitterion. The properties of the brain mitochondrial...Continue Reading

References

Apr 10, 1991·European Journal of Biochemistry·S SobollB Ziegler
Oct 5, 1990·European Journal of Biochemistry·S PassarellaE Quagliariello
Nov 15, 1985·Archives of Biochemistry and Biophysics·R A ShapiroN P Curthoys
Apr 1, 1973·Journal of Neurochemistry·G SvennebyE Kvamme
Jul 1, 1974·The Journal of Clinical Investigation·W Adam, D P Simpson
Jul 1, 1972·Journal of Neurochemistry·L R GjessingO Sjaastad
Sep 20, 1968·Archives of Biochemistry and Biophysics·S S Hotta
Jun 1, 1981·Journal of Neurochemistry·E Kvamme, B E Olsen
Oct 16, 1984·Biochimica Et Biophysica Acta·T Strzelecki, A C Schoolwerth
Jan 24, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Sahai
Jan 1, 1983·Neurochemical Research·E KvammeI A Torgner
Sep 30, 1981·Biochemical and Biophysical Research Communications·T Strzelecki, A C Schoolwerth
Jan 1, 1980·The International Journal of Biochemistry·Z KovacevićM Pavlovic
Jan 1, 1993·Developmental Neuroscience·M YudkoffM Erecinska
Jan 1, 1993·Progress in Biophysics and Molecular Biology·F Fonnum
May 3, 1996·The Journal of Biological Chemistry·E A López-BeltránS Cerdán
Dec 1, 1996·Cell Biochemistry and Function·J Ovádi, P A Srere
Feb 1, 1997·Trends in Biochemical Sciences·C A MannellaK Buttle
Oct 6, 1998·Neurochemistry International·M Dolińska, J Albrecht
May 1, 2010·Biomolecular Concepts·Javier MárquezFrancisco J Alonso

❮ Previous
Next ❯

Citations

Apr 11, 2012·Neurochemical Research·Tore EidTih-Shih W Lee
Feb 8, 2005·Journal of the American Society for Mass Spectrometry·Seonghee AhnScott Gronert
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·José M MatésJavier Márquez
Aug 27, 2005·Mitochondrion·Salvatore PassarellaLidia de Bari
May 18, 2011·The International Journal of Neuroscience·E V StelmashookL G Khaspekov
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·A Kelly, C A Stanley
Jan 20, 2018·Oxidative Medicine and Cellular Longevity·Musalmah MazlanHanafi Ahmad Damanhuri
Sep 12, 2007·Journal of Neuroscience Research·Mary C McKenna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.