PMID: 11921661Mar 30, 2002Paper

Glutaraldehyde fixation revisited

Journal of Long-term Effects of Medical Implants
M E Nimni

Abstract

Our ability to stabilize animal heart valves and to manufacture equivalent prostheses using collagenous tissues has proven to be of significant value to large number of patients over the last 30 years. Such tissue-derived bioprostheses are being gradually improved by modifications of design and slight changes in the processing of the tissues from which they originate. Nevertheless their durability does not seem to have significantly improved, and some of their drawbacks, such as their propensity to calcify, have not been eliminated. Because of this children are excluded from receiving such implants. Enhancing such structures using cells from various sources or with the aid of growth factors does not seem likely to succeed because such inert matrices are not compatible with growth and remodeling. On the other hand, stabilizing these structures by means of novel crosslinking approaches, the addition of "plasticizing" molecules, or the addition of covalently bound residues that inhibit the growth of mineral deposits, could prove to be practical ways of improving such devices.

Citations

Dec 8, 2010·Periodontology 2000·Jonas A RodriguesKlaus W Neuhaus
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Illen C LibioNádya P da Silveira
Jul 28, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sungwoo KimBo Han
Feb 15, 2008·Macromolecular Bioscience·Bai-Shuan LiuShr-Shin Fang
Jul 1, 2010·Reports on Progress in Physics·T DurduranA G Yodh
Mar 7, 2006·Expert Review of Medical Devices·Gemma ConnAlexander M Seifalian
Apr 8, 2014·Parasitology·A Hombach, J Clos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.