PMID: 402119Feb 1, 1977

Glutaraldehyde (pentanedial) allergic contact dermatitis. Usage test on sole and antecubital fossa: regional variations in response

Archives of Dermatology
H I Maibach, S D Prystowsky


Glutaraldehyde (pentanedial) is an effective topical therapeutic agent for patients with hyperhidrosis of the soles. A usage test was performed on the soles and antecubital fossae of six previously documented glutaraldehyde-sensitive subjects. All had negative usage test reactions to 25% glutaraldehyde on the soles. But when tested on the antecubital fossae with 2.5% glutaraldehyde, they developed a severe dermatitis within 48 hours. These data demonstrate a striking variation by which glutaraldehyde-sensitive patients tolerate or react to its use in two diverse anatomic sites.


Apr 1, 1991·British Journal of Clinical Pharmacology·K KubotaK Yasuda
Jan 11, 1992·Critical Reviews in Toxicology·R O BeauchampF W Kari
May 1, 1988·Gastrointestinal Endoscopy·D S Levine
Jan 1, 1985·Archives of Dermatological Research·W G ReifenrathP B Robinson

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