Glutaraldehyde-resistant Mycobacterium chelonae from endoscope washer disinfectors

Journal of Applied Microbiology
P A GriffithsA P Fraise

Abstract

Glutaraldehyde is used to disinfect flexible and other heat-sensitive endoscopes often with the aid of automated systems. Mycobacterium chelonae is being isolated with increasing frequency from these washer disinfectors and processed endoscopes. This has, on occasions, led to misdiagnosis and iatrogenic infections. Recent reports suggest that disinfecting machines, on a sessional or regular basis, with 2% glutaraldehyde may have selected and therefore encouraged the growth of strains of Myco. chelonae, possibly in biofilm, with decreasing susceptibility to glutaraldehyde. In view of this, the resistance of three strains of Myco. chelonae var. chelonae (the type strain NCTC 946 and two machine isolates) was tested against 2% glutaraldehyde and a wide range of alternative disinfectants. Disinfectants tested were a chlorine releasing agent, sodium dichloroisocyanurate at 1000 ppm and 10,000 ppm av Cl, 0.35% peracetic acid (NuCidex, Johnson & Johnson), 70% industrial methylated spirit (IMS), 1% peroxygen compound ('Virkon', Antec International) and 10% succine dialdehyde ('Gigasept', Sanofi Winthrop). Suspension and carrier tests were carried out in the presence and absence of an organic load. Results showed the type strain, which ...Continue Reading

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