Glutaraldehyde test for the rapid diagnosis of pulmonary and extra-pulmonary tuberculosis in an area with high tuberculosis incidence

Memórias do Instituto Oswaldo Cruz
Ben Hadj Hassine AhmedBoukadida Jalel

Abstract

Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide. The primary method for controlling TB is the rapid and accurate identification of infected individuals. Immune response exploitation represents one of the main methods used for early TB diagnosis; however, few studies have reported that whole blood originating from TB-infected patients gels faster in the presence of aldehyde than blood originating from healthy subjects, which is the focus of the current study. The study objectives are to determine the diagnostic value of a glutaraldehyde test (GT) in pulmonary tuberculosis (PTB) and extra-pulmonary tuberculosis (EPTB) and to assess its performance compared with light-emitting diode fluorescence microscopy (LED-FM). This study included 272 specimens (176 suspected PTB specimens and 96 suspected EPTB specimens). Of the 272 patients, 98 patients had TB infection confirmed by culture (64 PTB cases and 34 EPTB cases), and 174 patients had no TB infection. The gold standard technique (culture) was used as reference to verify the GT's performance. The GT showed a high sensitivity (96.9%) and specificity (82.1%) for PTB with a good positive predictive value (PPV = 75.6%) and negative predictive va...Continue Reading

References

Apr 1, 1990·Annals of Tropical Medicine and Parasitology·S LarssonK B Shrestha
Jun 1, 1996·British Journal of Haematology·S C RobsonP Jacobs
Jan 7, 1999·The European Respiratory Journal·Y BüyükaşikS V Dündar
Aug 26, 2006·The Lancet Infectious Diseases·Karen R SteingartMadhukar Pai
Sep 5, 2009·Diagnostic Microbiology and Infectious Disease·Walid Ben-SelmaJalel Boukadida

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Methods Mentioned

BETA
biopsy
fluorescence
Fluorescence microscopy
X-ray

Software Mentioned

. EXE epidemiology
LED
EPI7

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