Sep 1, 1976

Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis

Journal of the National Cancer Institute
S FialaH P Morris

Abstract

Continued administration of several hepatocarcinogens led to an increase in the concentration of glutathione (GSH) in the livers of intact, but not of hypophysectomized or adrenalectomized rats. The concentration of GSH remained high untill the development of hyperplastic nodules. Subsequently, the concentration of GSH dropped to the normal level or below. A single dose of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) produced an increase of GSH which, within a certain range, depended upon the amount of the carcinogen. In well differentiated, slowly growing hepatomas, the concentration of GSH approached the level in normal adult rat liver. On the other hand, in nondifferentiated and rapidly growing hepatomas, GSH was only 30-40% of that in normal liver. The activity of gamma-glutamyl transpeptidase (GTase) increased within 24-48 hours after a single large dose of 3'-Me-DAB. Continued feeding of 3'-Me-DAB led to an exponential increase of GTase. During hepatocarcinogenesis, the level of GTase activity corresponded to the degree and size of pathologic changes produced in rat liver. Chloramphenicol partially inhibited the increase of GTase induced by 2-acetylaminofluorene. Pretreatment with 3-methylcholanthrene partially inhibit...Continue Reading

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Mentioned in this Paper

Hepatocarcinogenesis
20-Methylcholanthrene
Ggt1
Chemical Carcinogenesis
Gamma-glutamyl transferase
p-Dimethylaminoazobenzene, (Z)-Isomer
Liver Carcinoma
Methylcholanthrene
Puromycin Dihydrochloride
Gamma Glutamyl Transferase Measurement

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