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Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro

Chemical Research in Toxicology

Jan 1, 1993

Mary C DavisThomas A Baillie

PMID: 8318660

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Abstract

The antitumor agent N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) is known to be unstable in aqueous solution, and to degrade spontaneously to reactive alkylating and carbamoylating intermediates. Whereas the alkylating component is believed to be responsible for the antitumor effects of...read more

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Glutathione Reductase
Antineoplastic Agents
2-chloroethyl isocyanate
Drug Stability
Bile Fluid
S-((2-chloroethyl)carbamoyl)glutathione
Acetylcysteine
1-(2-chloroethyl)-1-nitrosourea
Acetylcysteine, (DL)-Isomer
Rats, Holtzman
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Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro

Chemical Research in Toxicology

Jan 1, 1993

Mary C DavisThomas A Baillie

PMID: 8318660

DOI:

Abstract

The antitumor agent N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) is known to be unstable in aqueous solution, and to degrade spontaneously to reactive alkylating and carbamoylating intermediates. Whereas the alkylating component is believed to be responsible for the antitumor effects of...read more

Mentioned in this Paper

Glutathione Reductase
Antineoplastic Agents
2-chloroethyl isocyanate
Drug Stability
Bile Fluid

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Paper Details
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  • References
  • Citations15
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  • Citations15
12

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