PMID: 543Sep 1, 1975

Glutathione (author's transl)

Klinische Wochenschrift
H C Benöhr, H D WALLER

Abstract

Glutathione plays an important role in biology and medicine. Most cells of plants and animals contain high concentrations of reduced glutathione and a much smaller amount of oxidised glutathione. GSH is important for several metabolic functions of live cells, e.g. the protection of oxidative stress by peroxides, mediation of enzyme reactions, regulation of metabolic events, transport of amino acids across cell membranes via the gamma-glutamyl cycle, elimination of foreign compounds by GSH-conjugation, release of neurotransmitter substances. Irreversible perturbations of the glutathione metabolism may be the reason for severe clinical symptoms of hemolytic anemia or, perhaps, of central nervous disease.

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Citations

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Related Concepts

Microangiopathic Hemolytic Anemia
Metazoa
Plasma Membrane
Erythrocytes
Gamma-glutamyl transferase
Deficiency of glucose-6-phosphate Dehydrogenase
Reduced Glutathione
Yb-Glutathione-S-Transferase
Heinz Bodies
Hemoglobinopathies

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