PMID: 42902Nov 1, 1979

Glutathione: interorgan translocation, turnover, and metabolism

Proceedings of the National Academy of Sciences of the United States of America
O W Griffith, A Meister

Abstract

Glutathione is translocated out of cells; cells that have membrane-bound gamma-glutamyl transpeptidase can utilize translocated glutathione, whereas glutathione exported from cells that do not have appreciable transpeptidase enters the blood plasma. Glutathione is removed from the plasma by the kidney and other organs that have transpeptidase. Studies in which mice and rats were treated with buthionine sulfoximine, a selective and potent inhibitor of gamma-glutamylcysteine synthetase and therefore of glutathione synthesis, show that glutathione turns over at a significant rate in many tissues, especially kidney, liver, and pancreas; the rate of turnover in mouse skeletal muscle is about 60% of that in the kidney. Experiments on rats surgically deprived of one or both kidneys and treated with the gamma-glutamyl transpeptidase inhibitor D-gamma-glutamyl-(o-carboxy)phenylhydrazide establish that extrarenal gamma-glutamyl transpeptidase activity accounts for the utilization of about one-third of the total blood plasma glutathione. Normal animals treated with the transpeptidase inhibitor excrete large amounts of glutathione in their urine. They also excrete gamma-glutamylcysteine, suggesting that cleavage of glutathione at the cyste...Continue Reading

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Citations

Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J S Cornell, A Meister
Jan 1, 1976·Annual Review of Biochemistry·A Meister, S S Tate
Feb 1, 1978·FEBS Letters·G M Bartoli, H Sies
Mar 20, 1978·Biochimica Et Biophysica Acta·R HahnL Flohé
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·O W GriffithA Meister
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·O W GriffithA Meister
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S S TateA Meister
Jul 14, 1978·Biochemical and Biophysical Research Communications·P MoldéusS Orrenius
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S S TateA Meister
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P Van Der WerfA Meister
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·L L RossA Meister
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R Sekura, A Meister

Related Concepts

Metabolic Process, Cellular
Ggt1
Ggt1
Urine
Microvilli
Amino Acids, I.V. solution additive
Gamma-glutamyl transferase
Glutamate-Cysteine Ligase
Benign Tumor of Pancreas
Nephrectomy

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