Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes

Metabolism: Clinical and Experimental
Kamel MohammediGilberto Velho

Abstract

Glutathione peroxidase (GPX) is a class of antioxidant enzymes that catalyze the reduction of hydrogen peroxide to water. GPX1 is the most abundant isoform and is expressed in all kidney cells. Isoprostane and advanced oxidation protein products (AOPP) were identified as markers of oxidative stress in patients with kidney disease. We investigated associations of GPX1 genotypes with kidney complications, and with plasma concentrations of isoprostane and AOPP in type 1 diabetic patients. Four SNPs in the GPX1 gene region were genotyped in SURGENE (n=340; 10-year follow-up); GENEDIAB (n=461) and GENESIS (n=584) cohorts of type 1 diabetic patients. Subsets of GENEDIAB (n=237) and GENESIS (n=466) participants were followed up for 9 and 5years, respectively. Plasma concentrations of isoprostane and AOPP were measured at baseline in GENEDIAB. Hazard ratios (HR) were estimated for incidence of kidney complications. In SURGENE, 98 renal events (new cases of microalbuminuria or progression to more severe stage of diabetic nephropathy) occurred during follow-up. The minor T-allele of rs3448 was associated with the incidence of renal events (HR 1.81, 95% CI 1.16-2.84, p=0.008). In GENESIS/GENEDIAB pooled study, end stage renal disease (ESR...Continue Reading

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Citations

Jan 13, 2017·Preventive Nutrition and Food Science·Myung-Sook ChoiUn Ju Jung
Apr 12, 2018·Canadian Journal of Physiology and Pharmacology·Yuanfa YaoHanbing Li
Sep 25, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xuan YangXiaoyun He
May 27, 2017·BMC Complementary and Alternative Medicine·Xiao-Dan RenYa-Rong Li
Aug 23, 2020·Antioxidants·Alina Podkowińska, Dorota Formanowicz
May 2, 2018·Clinical & Translational Immunology·Raelene J PickeringJudy B de Haan
May 26, 2018·Free Radical Biology & Medicine·Jia-Qiang HuangXin Gen Lei

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