Glutathione peroxidase and oxidative stress

Toxicology Letters
J H Doroshow

Abstract

In this study, overexpression of the cDNA for the major cytoplasmic glutathione peroxidase isoenzyme, GSH Peroxidase 1 (GSHPx-1), in human MCF-7 breast cancer cells has been shown to significantly increase the tolerance of these cells to oxidative stress produced by hydrogen peroxide or by the redox cycling of the quinone-containing anticancer agent doxorubicin. These experiments suggest that intracellular detoxification of hydrogen peroxide by the glutathione-glutathione peroxidase cycle plays a critical role in resistance against oxidant stress produced by xenobiotics.

References

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Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K H CowanC E Myers

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Citations

Jun 25, 1998·International Journal of Cancer. Journal International Du Cancer·T E MeyerA M Bode
Jan 5, 2002·Comprehensive Therapy·D P Pandya
May 30, 1998·Biochemical Pharmacology·N R BachurR Hickey
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Mar 21, 2012·Basic & Clinical Pharmacology & Toxicology·Kadir BatciogluMustafa B A Djamgoz
Mar 4, 2014·BioMed Research International·Summaya M DhiyaaldeenMahmood Ameen Abdulla
Sep 30, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Christine Susara du PlooyRuan Kruger
Mar 25, 2018·IUBMB Life·Antonio Luiz Gomes JúniorAna Amélia de Carvalho Melo-Cavalcante

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