PMID: 2492138Jan 1, 1989Paper

Glutathione peroxidase and selenium deficiency in patients receiving home parenteral nutrition: time course for development of deficiency and repletion of enzyme activity in plasma and blood cells

The American Journal of Clinical Nutrition
H J CohenP Liegey

Abstract

The time course for the depletion of red blood cell (RBC) and plasma glutathione peroxidase (GSHPx) activity in five patients receiving home parenteral nutrition was documented. During the development of the RBC GSHPx deficiency, enzymatic activity and protein content decreased. Plasma and RBC selenium content were similarly decreased as was cellular metabolism of exogenous hydrogen peroxide. When the replacement of Se (selenious acid) began, there was a rapid increase (within 6 h) in plasma GSHPx activity. Platelet and granulocyte (PMN) GSHPx activity, which were low when Se replacement began, became normal within a time consistent with the kinetics of platelet and PMN production. RBC GSHPx did not become normal for 3-4 mo. This is consistent with the time course for RBC production. It appears that the repletion of blood cell GSHPx requires the formation of these cells in the presence of Se.

Citations

May 1, 1993·Biological Trace Element Research·V KorunováM Stýblo
Jul 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·T RannemB Akesson
Jan 14, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Larissa LagoGiselle Cerchiaro
Dec 15, 2019·Cells·Muhammad Umair, Majid Alfadhel
Sep 25, 2001·BioFactors·R F BurkA K Motley
Feb 27, 2004·European Journal of Clinical Nutrition·C D Thomson
Aug 1, 1992·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·C K AbramsH Mezghebe
Mar 1, 1997·The Proceedings of the Nutrition Society·C R Pennington
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May 1, 1997·Biological Trace Element Research·A MatsudaY Itokawa
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May 1, 1991·Archives of Biochemistry and Biophysics·R S EsworthyJ H Doroshow

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