PMID: 9523859Apr 2, 1998Paper

Glutathione peroxidase is not a functional marker of selenium status in the neonatal period

Journal of Pediatric Gastroenterology and Nutrition
L A DanielsK Simmer

Abstract

The antioxidant enzyme glutathione peroxidase is a selenoprotein that, in adults with low selenium intakes, has a strong linear relationship with blood selenium and hence is used as a functional indicator of selenium status. Our aim was to evaluate glutathione peroxidase as a functional marker of selenium status in preterm infants. Erythrocyte glutathione peroxidase activity and plasma and erythrocyte selenium were measured between days 1-5 and then weekly until discharge in 63 preterm infants with mean +/- standard error birth weight and gestation of 1572+/-60g and 30.7+/-0.3 weeks. A healthy reference group of term infants (n = 46) was assessed at day 5 and at 6 weeks. In preterm infants, over the first 3 months, the association of glutathione peroxidase activity with erythrocyte selenium was weak and inconsistent and nonexistent with selenium intake or plasma selenium. No correlations between any of these indicators were evident for term infants. In preterm infants, plasma and erythrocyte selenium declined over the first 6 weeks (p < 0.01), while glutathione peroxidase activity increased (p < 0.05). In term infants, plasma selenium increased (p < 0.001), but there was no change in erythrocyte selenium or glutathione peroxida...Continue Reading

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Citations

Sep 30, 1999·Cancer Letters·M R Ros-BullónJ H Martínez-Liarte
May 26, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Imad R MakhoulRaanan Shamir
Dec 28, 1999·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·D VitouxP Chappuis
Apr 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Andrea LouiMichael Obladen
May 2, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Niccolò NassiGianpaolo Donzelli
Feb 26, 2000·Clinics in Perinatology·P J Aggett
Jul 27, 2001·The Journal of International Medical Research·H KajiyamaS Kohno
Jan 5, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Rachael Tindell, Trent Tipple
Mar 22, 2007·European Journal of Clinical Nutrition·A LouiV N de Braetter
Jul 11, 2008·The American Journal of Clinical Nutrition·Lynne DanielsMaria Makrides

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