Glutathione plays an essential role in nitric oxide-mediated iron-deficiency signaling and iron-deficiency tolerance in Arabidopsis

The Plant Journal : for Cell and Molecular Biology
Varanavasiappan ShanmugamKuo-Chen Yeh

Abstract

Iron (Fe) deficiency is a common agricultural problem that affects both the productivity and nutritional quality of plants. Thus, identifying the key factors involved in the tolerance of Fe deficiency is important. In the present study, the zir1 mutant, which is glutathione deficient, was found to be more sensitive to Fe deficiency than the wild type, and grew poorly in alkaline soil. Other glutathione-deficient mutants also showed various degrees of sensitivity to Fe-limited conditions. Interestingly, we found that the glutathione level was increased under Fe deficiency in the wild type. By contrast, blocking glutathione biosynthesis led to increased physiological sensitivity to Fe deficiency. On the other hand, overexpressing glutathione enhanced the tolerance to Fe deficiency. Under Fe-limited conditions, glutathione-deficient mutants, zir1, pad2 and cad2 accumulated lower levels of Fe than the wild type. The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1. Furthermore, we found that zir1 had a lower accumulation of nitric oxide...Continue Reading

References

May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·D EideM L Guerinot
Jan 26, 1999·Archives of Biochemistry and Biophysics·Y JiJ A Thomas
Mar 6, 1999·Nature·N J RobinsonM L Guerinot
Jun 22, 1999·Current Opinion in Plant Biology·S Mori
Jan 12, 2001·Plant Physiology·M L Guerinot, D E Salt
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N MochizukiJ Chory
May 16, 2002·The Journal of Biological Chemistry·Katalin SiposGyula Kispal
Aug 21, 2002·Genome Biology·Erin L Connolly, Mary Guerinot
Dec 14, 2002·Plant Physiology·Magdalena GrazianoLorenzo Lamattina
Feb 6, 2003·Planta·Rüdiger Hell, Udo W Stephan
Apr 25, 2003·Trends in Plant Science·Wolfgang Schmidt
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·Graham Noctor, Christine H. Foyer
Jul 17, 2004·The Plant Journal : for Cell and Molecular Biology·Raymond J DiDonatoElsbeth L Walker
Jan 12, 2005·Trends in Plant Science·Magdalena Graziano, Lorenzo Lamattina
Nov 3, 2005·Journal of Experimental Botany·Biyan ZhouBingru Huang
Dec 22, 2005·The Plant Journal : for Cell and Molecular Biology·Jo BrightSteven J Neill
Jan 18, 2006·The Plant Journal : for Cell and Molecular Biology·Yasuhiro IshimaruNaoko K Nishizawa
Apr 17, 2007·Current Opinion in Plant Biology·Jean-François BriatFrédéric Gaymard
May 1, 2007·Plant Physiology and Biochemistry : PPB·Petra BauerMary Lou Guerinot
May 9, 2007·FEBS Letters·Sun A Kim, Mary Lou Guerinot
Sep 26, 2007·The Plant Journal : for Cell and Molecular Biology·Magdalena Graziano, Lorenzo Lamattina
Jan 22, 2008·Biochimica Et Biophysica Acta·Des R Richardson, Hiu Chuen Lok
Aug 30, 2008·Current Opinion in Plant Biology·Elsbeth L Walker, Erin L Connolly

❮ Previous
Next ❯

Citations

Jan 11, 2016·The Plant Journal : for Cell and Molecular Biology·Xing-Guang DengHong-Hui Lin
Aug 23, 2016·Frontiers in Plant Science·Khurram BashirNaoko K Nishizawa
Feb 6, 2018·The Plant Journal : for Cell and Molecular Biology·Sakthivel KailasamKuo-Chen Yeh
Mar 25, 2019·Journal of Experimental Botany·Agustina BuetMarcela Simontacchi
Nov 19, 2019·Journal of Experimental Botany·Gazaldeep KaurAjay Kumar Pandey
Mar 28, 2019·Frontiers in Plant Science·Francisco J RomeraRafael Pérez-Vicente
Feb 16, 2019·Frontiers in Plant Science·Sakthivel KailasamKuo-Chen Yeh
Sep 13, 2020·Journal of Experimental Botany·Ayelén Mariana DistéfanoGabriela Carolina Pagnussat
Jan 28, 2021·Journal of Experimental Botany·Khurram BashirNaoko K Nishizawa
Jun 3, 2021·International Journal of Molecular Sciences·María José GarcíaFrancisco Javier Romera
Jun 21, 2020·Ecotoxicology and Environmental Safety·Asiyeh GoodarziAli Abolhasani Soorki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.