Glutathione protects heavy metal-induced inhibition of hepatic microsomal ethoxyresorufin O-deethylase activity in Dicentrarchus labrax L

Ecotoxicology and Environmental Safety
M OliveiraM Pacheco

Abstract

The in vitro effects of chromium (Cr(VI)), copper (Cu2+), iron (Fe2+), mercury (Hg2+), and zinc (Zn2+) were assessed on liver microsomal ethoxyresorufin O-deethylase (EROD) activity from a sea bass (Dicentrarchus labrax L.) preexposed under laboratory conditions to 2.7 microM beta-naphthoflavone. The reduced glutathione (GSH) protection potential against heavy metal effects was also studied. The heavy metal concentration ranges used for this study were as follows: 10 pM-5 mM Cr(VI), 10 pM-100 microM Cu2+, 10 pM-1 mM Fe2+, 10 pM-10 microM Hg2+, and 10 pM-100 microM Zn2+. Liver microsomal EROD activity was significantly inhibited after in vitro exposure to Cr(VI) (500 microM), Cu2+ (1 microM), Fe2+ (100 microM), Hg2+ (100 pM), and Zn2+ (10 microM). Heavy metals inhibitory effect on liver EROD activity was ordered as follows: Hg2+ > Cu2+ > Zn2+ > Fe2+ > Cr(VI). Protective effects against Hg2+ (1 and 10 microM), Cu2+ (1, 10, and 100 microM), and Zn2+ (10, 50, and 100 microM) were observed in the presence of 0.5 mM GSH by a decrease in liver microsomal EROD activity inhibition. However, 0.5 mM GSH did not protect liver microsomal EROD activity from Cr(VI), and Fe2+-induced inhibition. The effect of metal mixtures (Cu(2+) + Zn(2+), Z...Continue Reading

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Citations

Mar 11, 2010·Archives of Environmental Contamination and Toxicology·M OliveiraM A Santos
Feb 25, 2014·Ecotoxicology and Environmental Safety·Luciana F OliveiraClaudia B R Martinez
Sep 8, 2010·Biological Trace Element Research·Mohamed Ali Medali BoujbihaAbdelfattah El Feki
Feb 16, 2016·The Science of the Total Environment·Mona ConnollyMaría L Fernández-Cruz
May 7, 2009·Expert Opinion on Drug Metabolism & Toxicology·Anwar Anwar-MohamedAyman Os El-Kadi
Dec 6, 2012·Ecotoxicology and Environmental Safety·M MelaH C Silva de Assis
Mar 3, 2012·Ecotoxicology and Environmental Safety·E KerambrunR Amara
Dec 7, 2007·The Science of the Total Environment·Denise FernandesCinta Porte
Feb 26, 2015·Annals of the New York Academy of Sciences·Maura BenedettiFrancesco Regoli
Apr 20, 2006·Ecotoxicology and Environmental Safety·N C Peixoto, M E Pereira
Nov 7, 2013·TheScientificWorldJournal·Gunasekaran BaskaranMohd Yunus Shukor
Apr 26, 2014·The Science of the Total Environment·Kathrin EichbaumHenner Hollert
Aug 12, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Milagrosa OlivaJosé Antonio Perales
Jul 11, 2006·Environmental Research·Denise FernandesMaria João Bebianno
Oct 4, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K VijayavelR H Richmond
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May 9, 2016·Environmental Science and Pollution Research International·Azza NaïjaAhmed Noureddine Helal
Oct 3, 2006·Ecotoxicology and Environmental Safety·Alaattin Sen, Asli Semiz
Feb 29, 2008·Ecotoxicology and Environmental Safety·I AhmadM A Santos

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