PMID: 8976642Nov 1, 1996Paper

Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis

Annals of the Rheumatic Diseases
D M MulherinR D Situnayake

Abstract

To measure erythrocyte glutathione reductase (EGR) activity and riboflavin status, and their relations to disease activity, in rheumatoid arthritis patients compared to healthy controls. Patients with rheumatoid arthritis were classified as active if there were features of articular inflammation which required initiation or change of disease modifying therapy, and as inactive if they had little evidence of articular inflammation. EGR was measured in patients and healthy controls by a functional assay with or without the addition of flavin adenine dinucleotide (FAD). The ratio of stimulated EGR (with FAD added) to basal EGR (no added FAD), which measures riboflavin status, is known as the EGR activation coefficient (EGRAC). An EGRAC > or = 1.3 represents biochemical riboflavin deficiency. 91 patients with rheumatoid arthritis, including 57 with active disease, and 220 healthy controls were studied. Both basal and stimulated EGR were significantly higher in patients with rheumatoid arthritis (P = 0.0001) than in controls. Biochemical riboflavin deficiency was identified in 41% controls and 33% patients with active rheumatoid arthritis but was significantly less frequent (9%) in patients with inactive compared to active disease (P...Continue Reading

References

Mar 1, 1990·The American Journal of Clinical Nutrition·T C CampbellB Parpia
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Feb 1, 1981·Rheumatology and Rehabilitation·R K Mallya, B E Mace
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Citations

Feb 14, 2002·Molecular Immunology·Takumi JikimotoShunichi Kumagai
Jun 1, 1997·Annals of the Rheumatic Diseases·R D Situnayake, G Kitas
Jan 31, 2008·Annals of Nutrition & Metabolism·Elisabeth FabianIbrahim Elmadfa
Nov 13, 2004·Arthritis Research & Therapy·Carol A Hitchon, Hani S El-Gabalawy
Aug 14, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Samuel Joshua PragasamMahaboobkhan Rasool
Feb 18, 2011·International Journal of Medical Sciences·Levent EdizMehmet Fethi Ceylan
Mar 22, 2014·The British Journal of Nutrition·Marziyeh Ashoori, Ahmad Saedisomeolia
Feb 18, 2016·Genome Medicine·Moran YassourCurtis Huttenhower
Dec 8, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Alain Cantagrel, Yannick Degboé
Nov 17, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Jovil KannampuzhaPauline B Darling
Jan 12, 2008·Biochemical and Biophysical Research Communications·Yukihito KabuyamaYoshimi Homma
Oct 5, 2011·Toxicology and Applied Pharmacology·Eric L KendigHoward G Shertzer
Feb 17, 2001·Journal of Applied Toxicology : JAT·M Q HassanS J Stohs
Feb 15, 2001·Arthritis Research·G SchettJ Smolen
Mar 21, 2020·Frontiers in Immunology·Yi-Shu HuangTrevor W Stone
Apr 20, 2018·Scientific Reports·Quentin Le BastardEmmanuel Montassier

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