Glutathione regeneration in calcium-loaded erythrocytes: a possible relationship among calcium accumulation, ATP decrement and oxidative damage

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
M Kurata, M Suzuki


Glutathione (GSH) regeneration was studied in rabbit erythrocytes which were loaded with calcium using ionophore A23187. Calcium-loading induced by A23187 and various concentrations of CaCl2 caused a dose-dependent depression in red cell GSH regeneration. The lowered GSH regeneration was mainly due to reduction of ATP level. In an experiment using haemolysate, the effect of calcium per se was negligible, while magnesium strongly affected GSH regeneration by controlling the rate of hexokinase reaction. These results indicate a possibility that cation perturbation, metabolic decay and oxidative damage are all interrelated in the erythrocyte aging process.


Jan 21, 1976·Biochimica Et Biophysica Acta·N S CohenD J Hanahan
Sep 1, 1976·Journal of Clinical Pathology·H L ReidT L Dormandy
Jun 15, 1975·Experientia·F H KirkpatrickP L La Celle
Jun 1, 1992·The American Journal of Physiology·A M FreedmanW B Weglicki
Dec 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Suzuki, M Kurata
Oct 14, 1985·Mechanisms of Ageing and Development·H ImanishiT Takino
Dec 1, 1986·Biochimica Et Biophysica Acta·J MurakamiT Shiga
Jun 1, 1985·Archives of Biochemistry and Biophysics·G FornainiM Dachà
Apr 11, 1985·Biochimica Et Biophysica Acta·T ShigaM Okazaki
Jan 1, 1980·Annals of the New York Academy of Sciences·F F VincenziB U Raess
Jan 1, 1983·Annual Review of Physiology·H J Schatzmann
Mar 20, 1981·Biochimica Et Biophysica Acta·S K Jain, S B Shohet
Apr 1, 1982·Mechanisms of Ageing and Development·S R Pfeffer, N I Swislocki
Nov 1, 1981·American Journal of Hematology·E A O'RearE C Lynch
May 1, 1980·Metabolism: Clinical and Experimental·W S WatsonT E Hilditch

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.