Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy

ACS Nano
Yijing LiuXiaoyuan Chen

Abstract

Designing nanomaterials with advanced functions and physical properties to improve cancer diagnosis and treatment has been an enormous challenge. In this work, we report the synthesis of magnetic gold nanowreaths (AuNWs) by combining wet-chemical synthesis with layer-by-layer self-assembly. The presence of Au branches, small junctions, and central holes in AuNWs led to improved photothermal effect compared with Au nanoring seeds and thick Au nanoring with smooth surface. The self-assembly of exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) on the surfaces of AuNWs not only effectively quenched the T1-weighted magnetic resonance imaging (MRI) ability due to the enhanced T2 decaying effect but also provided the responsiveness to glutathione (GSH). After intravenous injection, the T1 signal of magnetic AuNWs initially in the "OFF" state can be intelligently switched on in response to the relatively high GSH concentration in tumor, and the formation of larger assemblies of ES-MIONs improved their tumor delivery compared to ES-MIONs themselves. Thus, the magnetic AuNWs showed higher MRI contrast than ES-MIONs or commercial Magnevist in T1-weighted MR imaging of tumor. Furthermore, the magnetic AuNWs have absorption in ...Continue Reading

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Citations

Dec 18, 2018·Advanced Materials·Qinrui FuXiaoyuan Chen
May 16, 2019·Chemical Society Reviews·Wei TangXiaoyuan Chen
Mar 13, 2019·Annual Review of Analytical Chemistry·Guoxin RongHeather A Clark
Aug 30, 2019·Chemical Society Reviews·Lijiao YangXiaoyuan Chen
Oct 22, 2019·Journal of Biomolecular Structure & Dynamics·Yong-Chang LiuYan-Jun Hu
May 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fengrong ZhangHuiyu Liu
Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Aug 27, 2019·Chemistry : a European Journal·Zhen WangYapei Wang
Sep 12, 2019·Advanced Science·Minho KimJwa-Min Nam
Nov 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun DengJun Zhao
Dec 9, 2020·Advanced Materials·Mengyu ChangJun Lin
Mar 20, 2021·ACS Nano·Xuan ZhangHuanghao Yang
Oct 16, 2020·Biomaterials Science·Fang ChenDavid Myung
May 20, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Liang Ee LowDaishun Ling
Jun 23, 2021·Chemical Society Reviews·Xianwen WangLiang Cheng
Dec 12, 2018·Journal of the American Chemical Society·Nicolas MaciaBelinda Heyne

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