PMID: 8947308Nov 1, 1996Paper

Glutathione-S-transferase GST M1 "null" genotype and the risk of alcoholic liver disease

Alcoholism, Clinical and Experimental Research
V T SavolainenP J Karhunen

Abstract

The present study was conducted to investigate possible association between the occurrence of glutathione-S-transferase GST M1 "null" genotype and alcoholic liver disease (ALD). The"null" genotype indicating absent activity of class mu glutathione transferase was assessed in 33 abstainers, 43 moderate alcohol consumers, and 313 heavy alcohol consumers by polymerase chain reaction. The genotypes were compared with occurrence of alcoholic fatty liver, alcoholic hepatitis, and alcoholic liver fibrosis. The "null" genotype was found among 44.7% of patients in the series, with no significant differences between different consumption groups: controls, 36.4%; moderate consumers, 39.5%; and heavy consumers, 46.3%. Occurrence of GST M1 "null" genotype was not associated with occurrence ALD among moderate alcohol consumers. Frequency of the "null" genotype was, however, statistically nearly significantly [p = 0.07, odds ratio (OR) = 1.75] lower among heavy consumers with normal liver histology than in alcoholics with ALD. Furthermore, when compared with heavy consumers without ALD, the "null" genotype was nearly significantly more frequent among heavy consumers with at least slight liver fibrosis (p = 0.05, OR = 1.8) and statistically si...Continue Reading

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Citations

Sep 21, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E V BelogubovaE N Imyanitov
Jan 1, 2013·Asian Journal of Andrology·Sandro La VigneraAldo E Calogero
May 7, 2011·Journal of Gastroenterology and Hepatology·Devanshi SethChristopher P Day
May 14, 2010·Experimental Biology and Medicine·Maxwell Afari Gyamfi, Yu-Jui Yvonne Wan
Nov 8, 2008·European Journal of Gastroenterology & Hepatology·Mariana Machado, Helena Cortez-Pinto
Feb 24, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Felix Stickel, Christoph H Osterreicher
May 28, 2019·Journal of Clinical Medicine·Ylenia DucaSandro La Vignera
Nov 5, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A M BrindA A Fryer
Jun 4, 2005·Scandinavian Journal of Gastroenterology·José M LaderoJosé A G Agúndez
Sep 17, 2014·Molecular Biology Reports·Alfredo SantovitoMassimiliano Delpero
Oct 5, 2011·Alimentary Pharmacology & Therapeutics·M MarcosF-J Laso
Jul 10, 2021·World Journal of Hepatology·Vasyl PrysyazhnyukPetro Prysyazhnyuk
Mar 15, 2005·Clinics in Liver Disease·Charles S Lieber

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