PMID: 11328408May 1, 2001Paper

Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer: association with p53 expression and survival

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
R E HowellsR C Strange

Abstract

The objective of this study was to determine whether the association between GSTM1 null/GSTTI null and survival in ovarian cancer is mediated by the influence of these genes on p53 expression. In 81 women with pure invasive ovarian cancer, GSTM1 null and GSTT1 null genotypes were identified using polymerase chain reaction and p53 expression was assessed using immunohistochemistry. The association of these factors with survival was examined using Cox's proportional hazards regression models. Performance status (P < 0.001), operative stage (P = 0.004), residual disease (P = 0.001), histologic subtype (P = 0.05), tumor grade (P = 0.007), and the combined GSTMI null/GSTTl null genotype (P = 0.023) were all individually associated with survival. p53 expression was not associated with survival (P = 0.45). In a multivariate analysis, the effects of GSTM1 null/GSTT1 null on survival were lost when residual disease and tumor grade were included. The effects of p53 expression on survival were unchanged when residual disease, tumor grade, operative stage, and performance score were included. GSTM1 null/GSTT1null did not influence the effects of p53 expression on survival and vice versa. The GSTM1 null/GSTT1 null genotype was associated wi...Continue Reading

Citations

Oct 23, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Mariano MonzóRosa Artells
Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M BernardiniJ A Squire
Jun 23, 2010·Genetics and Molecular Research : GMR·A L OliveiraM B Melo
Sep 8, 2011·International Journal of Medical Sciences·Antonis ValachisEvangelos G Papanikolau
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·M NachtJ Jen
Jun 22, 2006·Journal of Cancer Research and Clinical Oncology·Elaine Cristina MorariLaura Sterian Ward
Apr 19, 2013·Journal of Cancer Research and Clinical Oncology·Linjuan XuZehua Wang
Jan 16, 2013·Journal of Oncology·Sreeja SarojiniK Stephen Suh
Aug 8, 2007·Current Opinion in Pharmacology·Hui-Wen Lo, Francis Ali-Osman
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R E J HowellsR C Strange
Jun 20, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Danyelle Townsend, Kenneth Tew
Aug 13, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Steven S Coughlin, Ingrid J Hall

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