PMID: 8955582Nov 1, 1996Paper

Glutathione-S-transferase induces murine dermatitis that resembles human atopic dermatitis

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C H HsuK H Hsieh

Abstract

The molecular and functional basis of allergen-induced inflammation seen in atopic dermatitis (AD) remains undefined. The objective of this study is to establish a murine model to dissect the pathological mechanisms of inflammatory reactions leading to the development of AD. An inbred strain of mice, BALB/c, when injected peritoneally with 30 micrograms of recombinant Sj26 protein (rSj26), a glutathione-S-transferase of Schistosoma japonicum worm, developed systematic dermatitis 21 days after immunization. The pathology of the dermatitis was examined by histological evaluation and immunostaining. The immediate skin hypersensitivity was demonstrated by serum transfer and skin test. Epicutaneous patch test was used to demonstrate the antigen-specific late phase response. Significant responses of rSj26-specific IgE were detected 2 weeks after immunization, and such changes paralleled formation of skin lesions. The diseased skin pathology showed inflammatory changes such as infiltration of mononuclear cells and eosinophils in the dermis and mild spongiosis in the epidermis. Numerous IgE bearing cells were also detected in the dermis. Peripheral blood showed eosinophilia at the same time. In addition, rSj26-specific positive skin te...Continue Reading

References

Jan 1, 1992·Dermatology : International Journal for Clinical and Investigative Dermatology·M K KägiB Wüthrich
Sep 1, 1990·Journal of Dermatological Science·Y TanakaH Yoshida
Jan 1, 1990·International Archives of Allergy and Applied Immunology·K Y ChuaW R Thomas
Dec 1, 1987·Immunology and Cell Biology·K M DavernG F Mitchell
May 1, 1989·The Journal of Clinical Investigation·E N CharlesworthL M Lichtenstein
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D B SmithG F Mitchell
Sep 1, 1987·Primary Care·A S Paller
Feb 1, 1988·The British Journal of Dermatology·C A Bruynzeel-KoomenP L Bruynzeel
Apr 1, 1988·The Journal of Allergy and Clinical Immunology·A D AdinoffR A Clark
Jun 1, 1988·The Journal of Allergy and Clinical Immunology·A J Frew, A B Kay
Jul 1, 1969·Archives of Dermatology·L JuhlinN Thyresson
Dec 1, 1973·Archives of Dermatology·S P StoneG J Gleich
Jan 1, 1993·The Journal of Clinical Investigation·J SalogaE W Gelfand
Feb 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P L BruijnzeelC A Bruijnzeel-Koomen

❮ Previous
Next ❯

Citations

Jul 26, 2003·The Journal of Investigative Dermatology·Chiung Hui HuangKaw Yan Chua
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
Apr 11, 2001·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.