Glutathione S-transferase M1 and T1 gene polymorphisms in Brazilian women with endometriosis

Journal of Assisted Reproduction and Genetics
Eloísa Helena KubiszeskiBianca Borsatto Galera

Abstract

The glutathione family (GST) genes appear to play a role in the genesis of endometriosis. This case-control study aimed to compare the frequencies of GSTM1 and GSTT1 polymorphisms in women with endometriosis and women without endometriosis. Polymerase chain reaction was performed to analyze the GSTM1 and GSTT1 genotypes among women with surgically and histologically confirmed endometriosis (case group n = 121) and in women without evidence of endometriosis confirmed by laparoscopy for investigation the infertility or for laparoscopic tubal sterilization (control group n = 97). No differences in the frequencies of GSTM1 polymorphism (null genotype) were observed between the cases and controls: odds ratio (OR) = 1.13; 95 % CI 0.656-1.93 (p = 0.659). The GSTT1 polymorphism (null genotype) was more prevalent in the endometriosis group than in the control group (OR = 0.53; 95 % CI 0.94-0.29 (p = 0.039). No relationship between menstrual cycle interval and GSTM1 null genotype frequency was observed in either cases or controls (p = 0.370 and p = 0.664, respectively). In addition, no relationship between menstrual cycle interval and GSTT1 null genotype was observed in cases (p = 0.797) or controls (p = 0.052). GSTM1 null genotype frequ...Continue Reading

References

Nov 1, 1991·Journal of Reproduction and Fertility·M RahillyD J Harrison
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jun 17, 1993·The New England Journal of Medicine·D L Olive, L B Schwartz
Mar 11, 2000·Human Reproduction Update·F Z Bischoff, J L Simpson
Apr 18, 2002·The Journal of the American Association of Gynecologic Laparoscopists·Charles ChapronBertrand Dousset
Mar 7, 2003·Fertility and Sterility·Demetrios A ArvanitisDemetrios A Spandidos
Jun 28, 2005·Human Reproduction·Stephen KennedyUNKNOWN ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group
Sep 23, 2008·Human Reproduction Update·C B TempferB C J M Fauser
May 4, 2010·Clinical Obstetrics and Gynecology·Albert L HsuPamela Stratton
May 28, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zahra HosseinzadehZiba Zahiri Sorouri
May 2, 2012·Environmental Health and Preventive Medicine·Yasunari MatsuzakaMinoru Kimura

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Citations

Dec 11, 2019·Human Reproduction Update·Loren MéarFrançois Vialard
Apr 17, 2019·Experimental and Therapeutic Medicine·Loukia VassilopoulouGeorge N Goulielmos
Dec 10, 2020·Revista da Associação Médica Brasileira·Mariana Mendes Porto AzevedoMariangela Torreglosa Ruiz Cintra

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