Glutathione-S-transferase M1 polymorphism and pro-inflammatory cytokines tumour necrosis factor-α and interleukin-1β are associated with preeclampsia in Serbian women

American Journal of Reproductive Immunology : AJRI
Tamara Sljivancanin JakovljevicJelena Milasin

Abstract

Preeclampsia has a multifactorial origin with genetic, immunological, and environmental factors described as main contributors to its onset. This study aimed to investigate glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) gene polymorphisms, the expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and the potential relationship between GST polymorphisms and cytokine expression levels in preeclampsia and uncomplicated pregnancy. This prospective case-control study included 50 women with preeclampsia and 50 healthy pregnant women. DNA and RNA were extracted from women leukocytes. Deletion polymorphisms were analyzed by PCR, while cytokine mRNA expression was analyzed by real-time PCR. GSTM1 null genotype with present GSTT1 increased the risk for preeclampsia development. Deletion of GSTT1 without deletion of GSTM1 increased the risk for early preeclampsia. Relative mRNA expression of TNF-α was significantly higher in preeclampsia compared to healthy pregnant women (P = 0.006). Expression of IL-1β was significantly higher in severe and late preeclampsia compared to the control group (P = 0.005, P = 0.007, respectively). A significant positive correlation between TNF-α and IL-1β was observed (...Continue Reading

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Citations

Jul 14, 2020·American Journal of Reproductive Immunology : AJRI·Tamara Sljivancanin JakovljevicJelena Milasin
Dec 10, 2020·Revista da Associação Médica Brasileira·Mariana Mendes Porto AzevedoMariangela Torreglosa Ruiz Cintra
May 7, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Keziban DoganMurat Dogan
Nov 13, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Igrid García-GonzálezLizbeth González-Herrera

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