PMID: 15344211Sep 3, 2004Paper

Glutathione S-transferase M1 status and breast cancer risk: a meta-analysis

Yonsei Medical Journal
Jae Woong SullChung Mo Nam

Abstract

It is not yet clear whether Glutathione S-transferase M1 (GSTM1) polymorphisms affect the risk of breast cancer. The aim of this study is to provide a comprehensive meta-analysis of all the available, published case-control studies on the extent of the possible association between GSTM1 polymorphisms and susceptibility to breast cancer. Twenty case-control studies on GSTM1 and breast cancer were identified using both PUBMED and a manual search. Meta-analysis was conducted by the Peto method. Subgroup analyses were undertaken, in order to explore the relationship between effect sizes and the study characteristics. The overall odds ratio (OR) was found to be 1.06 (95% CI, 0.99-1.14). The OR for post-menopausal women with GSTM1 deficiency was determined to be 1.19 (95% CI, 1.05-1.34). In populations with a low frequency of GSTM1 deficiency, a greater increase was observed (OR, 1.20; 95% CI, 1.08-1.34). Furthermore, the highest associations were found in post-menopausal women with a low frequency of GSTM1 deficiency (OR, 1.44; 95% CI, 1.20-1.73). The fact that GSTM1 deficiency is not rare in the general population implies that the attributable risk for breast cancer could be sizable. Further studies focusing on the structure of hap...Continue Reading

Citations

Jul 20, 2006·Human Genomics·Sharon A Savage, Stephen J Chanock
Mar 3, 2009·Journal of Cancer Research and Clinical Oncology·Wen-Lei ZhuoZheng-Tang Chen
Feb 21, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ke-Da YuZhi-Ming Shao
Mar 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong ZhangQiu-ping Wang
Apr 23, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kerryn W RedingKathleen E Malone
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amanda B SpurdleJohn L Hopper
Jun 8, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Stéphanie Piacenti Dos SantosEny Maria Goloni-Bertollo
Dec 14, 2005·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Bibhesh K SinghBhagwan S Garg
Apr 3, 2009·Journal of Experimental & Clinical Cancer Research : CR·Xianlu ZhuoXueyuan Zhang

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