PMID: 9435885Jan 1, 1997Paper

Glutathione S-transferase-mediated induction of GC-->AT transitions by halomethanes in Salmonella

Environmental and Molecular Mutagenesis
D M DeMariniR Pegram

Abstract

Halomethanes are among the most common mutagenic and carcinogenic disinfection by-products present in the volatile/semivolatile fraction of chlorinated drinking water. Recent studies have demonstrated that the mutagenicity of dichloromethane (CH2Cl2) and bromodichloromethane (BrCHCl2) can be mediated by a theta-class glutathione S-transferase (GSTT1-1). These studies used strain RSJ100 of Salmonella, which is a derivative of the base-substitution strain TA1535 (hisG46, rfa, delta uvrB), into which has been cloned the GSTT1-1 gene from rat. In the present report, we have extended these studies by demonstrating that the mutagenicity of two additional brominated trihalomethanes, bromoform (CHBr3) and chlorodibromomethane (CICHBr2), are also mediated by GSTT1-1 in RSJ100. Using a Tedlar bag vaporization technique, the mutagenic potencies (revertants/ppm) for these two compounds as well as the compounds tested previously rank as follows: CHBr3 approximately CICHBr2 > BrCHCl2 approximately CH2Cl2. To explore the mutational mechanism, we determined the mutation spectra of all four halomethanes at the hisG46 allele by performing colony probe hybridizations of approximately 100 revertants induced by each compound. The majority (96-100%)...Continue Reading

Citations

Sep 26, 2009·Clinical and Experimental Medicine·Fang-Fang ZengBin-You Wang
Jun 1, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·David R GeterAnthony B DeAngelo
Mar 16, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J Fawell
Sep 26, 2002·Mutation Research·Vincent R TortiByron E Butterworth
Jul 2, 2003·Mutation Research·Stefano LandiDavid M DeMarini
Jul 24, 1998·Mutation Research·D M DeMarini
Feb 19, 2004·Journal of Carcinogenesis·David R GeterAnthony B DeAngelo
Jan 28, 2012·Environmental Health Perspectives·Zorimar Rivera-NúñezDavid A Savitz
Aug 3, 2010·Environmental Health Perspectives·Kenneth P CantorManolis Kogevinas
Sep 14, 2010·Environmental Health Perspectives·Manolis KogevinasRicard Marcos
Sep 13, 2011·International Journal of Environmental Research and Public Health·Glinda S CooperAmbuja S Bale
Oct 11, 2012·Journal of Biomedicine & Biotechnology·Andrea SaponeMoreno Paolini
Feb 4, 2016·Environmental Pollution·Jin-Young Min, Kyoung-Bok Min
Apr 8, 2004·International Journal of Cancer. Journal International Du Cancer·Jean-Marc FerrazPierre Laurent-Puig
Dec 14, 2011·Water Research·Julien ParinetJean-Luc Boudenne
Mar 10, 2012·Environmental and Molecular Mutagenesis·S LaingamA R Humpage
Feb 3, 2015·Environmental Toxicology·Ana I Faustino-RochaP A Oliveira

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