Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane off chloroform

Toxicology and Applied Pharmacology
R A PegramLarry D Claxton

Abstract

Trihalomethanes (THMs) are the most prevalent disinfection by-products identified in chlorinated drinking water. Among the THMs, chloroform (CHCl3) generally occurs at the highest concentration in finished water, but the concentrations of each of the brominated THMs (CHBrCl2, CHBr2Cl, and CHBr3) can exceed that of CHCl3. Each of these four THMs was carcinogenic in rodents in chronic oral dosing studies. This study assessed THM mutagenicity in a strain of Salmonella typhimurium TA1535 that was transfected with rat theta-class glutathione S-transferase T1-1 (+GST). The +GST strain and its nontransfected parent strain (-GST) were employed in a plate-incorporation assay and exposed for 24 hr to the vapor of individual THMs at concentrations up to 25,600 ppm in sealed Tedlar bags. Base-substitution revertants were produced in the +GST strain in a dose-dependent fashion by CHBrCl2 but not by CHCl3. At 4800 ppm CHBrCl2, which produced a calculated agar concentration of 0.67 mM, there were 419 +/- 75 revertants per plate compared to a spontaneous level of 23 +/- 5. CHCl3 produced a doubling of revertants only at the two highest concentrations tested (19,200 and 25,600 ppm). These results indicate that bromination of THMs confers the ca...Continue Reading

Citations

Jan 25, 2003·Journal of Biochemistry and Molecular Biology·F Peter Guengerich
Dec 2, 2005·American Journal of Epidemiology·Khaled KasimUNKNOWN Canadian Cancer Registries Epidemiology Research Group
Mar 10, 2009·Journal of Toxicology and Environmental Health. Part a·Richard J BullLinda K Teuschler
Mar 10, 2012·Environmental and Molecular Mutagenesis·S LaingamA R Humpage
Oct 11, 2012·Journal of Biomedicine & Biotechnology·Andrea SaponeMoreno Paolini
Nov 5, 2013·Environmental Health Perspectives·Leslie Thomas StaynerManolis Kogevinas
Jan 24, 2016·Applied and Environmental Microbiology·Xi Jia Ooi, Kai Soo Tan
May 6, 2019·Environmental Science and Pollution Research International·Zhenxing YaoRuibao Jia
May 7, 2020·Environmental and Molecular Mutagenesis·David M DeMarini
Feb 26, 2000·Carcinogenesis·F P Guengerich
Jun 11, 2002·Environmental Health Perspectives·Claire Infante-RivardDaniel Sinnett
Dec 13, 2005·Biochemistry. Biokhimii︠a︡·G V Smirnova, O N Oktyabrsky
Jan 29, 2011·Journal of Toxicology and Environmental Health. Part a·Hsin-Wei KuoChun-Yuh Yang
Sep 14, 2010·Environmental Health Perspectives·Manolis KogevinasRicard Marcos
Jan 9, 2013·Journal of Toxicology and Environmental Health. Part a·Shang-Shyue TsaiChun-Yuh Yang
Jan 28, 2012·Environmental Health Perspectives·Zorimar Rivera-NúñezDavid A Savitz
Aug 27, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Steve E HrudeyBenjamin D Stanford
Jun 11, 2002·International Journal of Toxicology·Michael H GeorgeAnthony B DeAngelo
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Hsin-Wei KuoChun-Yuh Yang
Aug 7, 2002·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M E MeekM Walker
Sep 9, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Mark J NieuwenhuijsenMireille Toledano
Oct 18, 2014·Environmental Health Perspectives·Paul M SchlosserGlinda S Cooper
Apr 7, 2012·Journal of Toxicology and Environmental Health. Part a·Yen-Hsiung LiaoChun-Yuh Yang
Dec 9, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Lucas A SalasNúria Malats
Aug 2, 2015·Current Environmental Health Reports·Cristina M VillanuevaPatrick Levallois
Apr 23, 2016·Journal of Water and Health·Emma SawadeMary Drikas
Jan 5, 2019·Environmental Science and Pollution Research International·Luciana de Castro MedeirosViviane Souza do Amaral
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Hsin-Wei KuoChun-Yuh Yang
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Hsin-Wei KuoChun-Yuh Yang
Aug 3, 2010·Environmental Health Perspectives·Kenneth P CantorManolis Kogevinas
Jul 28, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Teresa L LeavensRex A Pegram
Feb 27, 2015·Journal of Water and Health·Elisabet TeixidóJesús Gómez-Catalán
Jan 24, 2021·Environmental and Molecular Mutagenesis·David M DeMariniHannah K Liberatore
Mar 18, 1999·Toxicology and Applied Pharmacology·A H HammondJ R Fry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.