Glutathione-S-transferase P1 polymorphism and risk for essential tremor

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Carmen MartínezFélix Javier Jiménez-Jiménez

Abstract

Glutathione-S-transferases (GST) are polymorphic enzymes that participate in the metabolism of carcinogens (including those of tobacco smoke) and pesticides. We investigated the possible association between the GSTP1 genotype and allelic variants and the risk for essential tremor (ET). We studied the frequency of the GSTP1 genotypes and allelic variants in 200 patients with ET and 220 healthy controls using PCR-RFLP method. The association between GSTP1 polymorphism and the exposure to some environmental factors (agricultural work, pesticides, well-water and smoking-cigarettes habit) was also studied in a subgroup of patients. The frequencies of the GSTP1 genotypes and allelic variants did not differ significantly between patients with ET and controls or between patients with ET exposed to agricultural work, well water and cigarette smoking versus those non-exposed. Mutated allelic variants were significantly more frequent in patients with ET exposed to pesticides versus those non-exposed. GSTP1 polymorphism was unrelated with the age of onset of ET. GSTP1 genotypes and allelic variants were not related with the risk for ET with the possible exception of those patients exposed to pesticides.

References

Feb 28, 1987·Lancet·C J Bulpitt
Nov 1, 1995·Nature Medicine·M Swift
Mar 1, 1995·Toxicology Letters·C Di IlioA Aceto
Mar 1, 1997·Age and Ageing·J A AgúndezJ Benítez
Jan 1, 1997·European Neurology·J A AgúndezJ Benítez
Aug 10, 2000·Italian Journal of Neurological Sciences·G SalemiG Savettieri
Dec 12, 2001·British Journal of Clinical Pharmacology·A K Daly, C P Day
Dec 25, 2002·Neurology·E D LouisM Parides
Jan 14, 2003·Neuroscience Letters·Samir N KeladaHarvey Checkoway
Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Julián Benito-LeónJosé-Antonio Molina
Jun 20, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Simona PigulloPaola Mandich
Nov 5, 2003·Environmental Health Perspectives·Elan D LouisAndrew Todd
Apr 23, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erika L AbelDavid L Eaton
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Ali SazciKemal Bayulkem
Jan 25, 2005·Lancet Neurology·Elan D Louis
Sep 9, 2006·European Neurology·Hortensia Alonso-NavarroFélix Javier Jiménez-Jiménez
Oct 13, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lawrence I GolbeWilliams G Johnson
Jan 26, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R VilarM C Lechner
Jun 16, 2007·European Neurology·Félix Javier Jiménez-JiménezBeatriz Barcenilla
Sep 1, 2007·Clinical Neuropharmacology·Carmen MartínezFélix Javier Jiménez-Jiménez
Jul 2, 2008·Parkinsonism & Related Disorders·A Tallón-BarrancoJ A Molina

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Citations

Sep 18, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E K Tan, A H Schapira
Jan 12, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O Lorenzo-BetancorP Pastor
Aug 22, 2008·Neuroepidemiology·Elan D Louis
Aug 20, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni Mostile, Joseph Jankovic
May 21, 2013·Acta Neurologica Scandinavica·F J Jiménez-JiménezJ A G Agúndez
Apr 12, 2015·Expert Opinion on Therapeutic Targets·José Ag AgúndezElena García-Martín
Oct 18, 2014·Frontiers in Cellular Neuroscience·Diêgo Madureira de OliveiraRamon Santos El-Bachá
Apr 13, 2012·Molecular Biology International·César Paz-Y-MiñoMaría Eugenia Sánchez
Mar 10, 2017·European Journal of Clinical Investigation·José A G AgúndezFélix Javier Jiménez-Jiménez
Apr 20, 2018·Journal of Holistic Nursing : Official Journal of the American Holistic Nurses' Association·William E RosaMarianne Matzo
Aug 11, 2020·Tremor and Other Hyperkinetic Movements·Vasileios SiokasEfthimios Dardiotis
Jun 3, 2021·Pharmaceuticals·Félix Javier Jiménez-JiménezJosé A G Agúndez
Feb 20, 2009·Current Opinion in Pulmonary Medicine

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