Glutathione S-transferase T1 mismatch constitutes a risk factor for de novo immune hepatitis after liver transplantation

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Isabel AguileraAntonio Núñez-Roldán

Abstract

A new form of autoimmune hepatitis referred to as de novo, has been reported after liver transplantation during the past 5 years. The features are identical to those of classical autoimmune hepatitis (AIH), but the facts involved in the onset and outcome of this type of graft dysfunction are still unclear. The identification of antibodies directed to glutathione S-transferase T1 (GSTT1) in the sera of patients with de novo immune hepatitis led us to the description of an alloimmune reaction due to a GSTT1 genetic incompatibility between donor and recipient. We analyzed a cohort of 110 liver transplant patients treated in the liver transplant unit of our hospital during a period of 1 year, from September 2002 to October 2003. We found the following distribution of the GSTT1 genotypes (recipient/donor): +/+ = 66, +/- = 23, -/+ = 15, -/- = 6. Six of these patients were diagnosed with de novo immune hepatitis; all of them belong to the group of negative recipients with positive donors, and all produced anti-GSTT1 antibodies. This genetic combination is associated with a statistically significant increased risk of de novo immune hepatitis (IH) in liver transplant patients (P < .0001 by the Fisher exact test). In conclusion, our resu...Continue Reading

References

Mar 3, 1998·Lancet·N KerkarG Mieli-Vergani
Jan 6, 1999·Seminars in Liver Disease·R Whalen, T D Boyer
Jan 12, 1999·Transplantation·E PradosE Fabrega
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D E JonesM Hudson
Aug 10, 1999·Transplantation·P MilkiewiczE Elias
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G AyataU Khettry
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D J ReichP A Sheiner
Feb 24, 2001·Gastroenterology·A J Czaja, H A Homburger
Apr 17, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A González-KochR H Wiesner
Apr 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·H M HernandezE M Alonso
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A HeneghanJ G O'Grady
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Magdalena SalcedoGerardo Clemente
May 31, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Albert J Czaja
May 31, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ernesto P MolmentiGoran B Klintmalm
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Diego Vergani, Giorgina Mieli-Vergani
Nov 26, 2002·Seminars in Liver Disease·James Neuberger
Dec 16, 2003·Journal of Hepatology·Giorgina Mieli-Vergani, Diego Vergani

❮ Previous
Next ❯

Citations

Feb 22, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I Aguilera, A Nuñez-Roldan
May 22, 2007·Current Gastroenterology Reports·William R Treem
Sep 10, 2010·Hepatology International·Ye H OoDavid H Adams
May 28, 2005·Transplantation Proceedings·J Neuberger, D Jothimani
Mar 1, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Isabel AguileraAntonio Nuñez-Roldan
Apr 8, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Isabel AguileraAntonio Núñez-Roldán
Oct 29, 2011·Clinics in Liver Disease·Flavia MendesCynthia Levy
Jul 10, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luigi MuratoriMarco Lenzi
Dec 15, 2015·Clinical Transplantation·Isabel AguileraAntonio Núñez-Roldán
Mar 31, 2009·Transplantation Proceedings·M Desai, J Neuberger
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Isabel AguileraAntonio Nuñez-Roldan
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James Neuberger
Dec 2, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Aya Miyagawa-HayashinoToshiaki Manabe
May 9, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Teru KumagiJenny Heathcote
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R S VenickR W Busuttil
Jan 15, 2008·Clinical Transplantation·Kaname YoshizawaMasayuki Nakano
Sep 13, 2006·Transfusion·Ingeborg WichmannAntonio Núñez-Roldán
Mar 23, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Isabel AguileraAntonio Núñez-Roldán
Aug 21, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Desley A H Neil, Stefan G Hübscher
Jun 21, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Aldo J Montano-LozaAndrew L Mason
May 23, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·María José Martínez-BravoIsabel Aguilera
Mar 24, 2011·Journal of Hepatology·Stefan G Hübscher
Jun 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J DemetrisY Zen
Oct 7, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luis Ibáñez-SamaniegoRafael Bañares
May 10, 2012·Current Opinion in Organ Transplantation·Stefan G Hübscher
Dec 28, 2017·BioMed Research International·Maria Grazia ClementePietro Vajro
Oct 31, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Guido StirnimannAldo J Montano-Loza
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anthony J DemetrisFunda Yilmaz
Jun 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Obaid S Shaikh, A Jake Demetris
Apr 25, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Stefan G Hübscher
May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Anthony J Demetris, Mylene Sebagh
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael P Manns, Arndt Vogel
Oct 20, 2012·Expert Review of Clinical Immunology·Shishir ShettyStefan G Hubscher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Magdalena SalcedoRafael Bañares
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Magdalena SalcedoGerardo Clemente
© 2021 Meta ULC. All rights reserved