Glutathione S-transferase T1 status and gastric cancer risk: a meta-analysis of the literature

Mutagenesis
Stefania BocciaGualtiero Ricciardi

Abstract

To clarify the risk of gastric cancer associated with glutathione S-transferase T1 (GSTT1) status, a meta-analysis of published studies was performed. Eligible studies included all reports investigating an association between GSTT1 status and gastric cancer published before October 31, 2005. A qualitative scoring of papers was applied to evaluate the quality of the published data. The principal outcome measure was the odds ratio (OR) for the risk of gastric cancer associated with GSTT1 deletion status using a random effects model. Eighteen case-control studies detailing a possible association between the GSTT1 null genotype and gastric cancer were selected. Combining data from these studies, totalling 2508 cases and 4634 controls, a non-statistically significant OR for gastric cancer risk associated with GSTT1 deficiency emerged [OR = 1.09; 95% confidence interval (CI): 0.97-1.21; I(2) = 0%]. When only high-quality scored studies were considered, a statistically significant increased risk appeared (OR = 1.23; 95% CI: 1.04-1.45; I(2) = 0%), as well as considering only Caucasians (OR = 1.23; 95% CI: 1.03-1.56; I(2) = 0%). By pooling data from seven studies (319 cases and 656 controls) that considered combinations of GSTT1 and GST...Continue Reading

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Citations

May 29, 2008·JAMA : the Journal of the American Medical Association·Linda M DongUlrike Peters
Sep 26, 2009·Clinical and Experimental Medicine·Fang-Fang ZengBin-You Wang
Dec 5, 2009·World Journal of Gastroenterology : WJG·Jin-Mei PiaoSoo-Hyun Kim
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