Glutathione Stimulates Vitamin D Regulatory and Glucose-Metabolism Genes, Lowers Oxidative Stress and Inflammation, and Increases 25-Hydroxy-Vitamin D Levels in Blood: A Novel Approach to Treat 25-Hydroxyvitamin D Deficiency

Antioxidants & Redox Signaling
Sushil K JainJoseph A Bocchini

Abstract

25-Hydroxyvitamin D [25(OH)VD] deficiency/inadequacy is a major public health issue affecting more than 1 billion people worldwide. A convincing association exists between low levels of circulating 25(OH)VD and the poor health outcomes associated with chronic diseases. However, high supraphysiological doses of VD are needed to achieve the required 25(OH)VD levels in the blood, because many subjects respond poorly to supplementation. This study reports a link between 25(OH)VD deficiency and a reduction in glutathione (GSH) in obese adolescents. The improvement in GSH status that results from cosupplementation with VD and l-cysteine (LC; a GSH precursor) significantly reduced oxidative stress in a mouse model of 25(OH)VD deficiency. It also positively upregulated VD regulatory genes (VDBP/VD-25-hydroxylase/VDR) in the liver and glucose metabolism genes (PGC-1α/VDR/GLUT-4) in muscle, boosted 25(OH)VD, and reduced inflammation and insulin resistance (IR) levels in the blood compared with supplementation with VD alone. In vitro GSH deficiency caused increased oxidative stress and downregulation of VDBP/VD-25-hydroxylase/VDR and upregulation of CYP24a1 in hepatocytes and downregulation of PGC-1α/VDR/GLUT-4 in myotubes. This study dem...Continue Reading

References

Nov 1, 1989·The British Journal of Nutrition·J ViñaJ R Viña
Jan 23, 1999·The Journal of Clinical Investigation·F F SafadiN E Cooke
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Isabella Dalle-DonneRoberto Colombo
May 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey B ChengDavid W Russell
Jul 7, 2005·Antioxidants & Redox Signaling·Joseph L EvansIra D Goldfine
Dec 17, 2005·Antioxidants & Redox Signaling·Asnat Bloch-Damti, Nava Bashan
May 16, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marijn SpeeckaertYouri E C Taes
May 13, 2008·The American Journal of Clinical Nutrition·Victor L Fulgoni
Sep 25, 2008·Molecular Aspects of Medicine·Christopher C FranklinTerrance J Kavanagh
Aug 19, 2009·Antioxidants & Redox Signaling·Esther Barreiro, Sabah N A Hussain
Sep 5, 2009·American Journal of Hypertension·Rudolph SchutteLeoné Malan
Nov 13, 2009·Diabetes Care·Ralph A DeFronzo, Devjit Tripathy
Sep 16, 2010·Amino Acids·Xilong LiGuoyao Wu
Dec 18, 2010·Free Radical Biology & Medicine·Justin L Rains, Sushil K Jain
Jan 21, 2011·The New England Journal of Medicine·Clifford J Rosen
Oct 12, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Robert A McPherson, Gil Hardy
Nov 15, 2011·Recent Patents on Endocrine, Metabolic & Immune Drug Discovery·Broden J MorganAnthony L Albiston
Feb 7, 2012·Antioxidants & Redox Signaling·Anne M FitzpatrickLou Ann S Brown
Mar 27, 2012·Archives of Biochemistry and Biophysics·J S Adams, M Hewison
Apr 17, 2012·Archives of Biochemistry and Biophysics·Yongji WangHector F DeLuca
Jun 5, 2012·Antioxidants & Redox Signaling·Rodrigo Franco, John A Cidlowski
Jun 30, 2012·Trends in Endocrinology and Metabolism : TEM·Jessica M CurtisDavid A Bernlohr
Jul 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ilaria BarchettaMaria Gisella Cavallo
Jul 5, 2012·The American Journal of Clinical Nutrition·Elizabeth Garrett-MayerSebastiano Gattoni-Celli
Feb 7, 2013·British Journal of Clinical Pharmacology·Sandra Maria SaccoElizabeth Offord
Oct 17, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Yu ZhouJoan M Lappe
Jun 3, 2014·The Journal of Clinical Endocrinology and Metabolism·K S JonesI Schoenmakers
Mar 31, 2015·Molecular and Cellular Endocrinology·Richard D Lewis, Emma M Laing
May 2, 2015·Molecular Nutrition & Food Research·Jie YinGuoyao Wu
Nov 17, 2015·Metabolic Syndrome and Related Disorders·Prasenjit Manna, Sushil K Jain
Jan 19, 2016·The Journal of Steroid Biochemistry and Molecular Biology·David A JolliffeAdrian R Martineau
Apr 10, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Walter L Miller
May 7, 2016·Nature Reviews. Cardiology·Stefan PilzWinfried März
May 18, 2016·Metabolic Syndrome and Related Disorders·Roy C ParishSushil K Jain
Oct 14, 2016·Antioxidants & Redox Signaling·Jong-Lyel RohDaiha Shin

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Citations

Mar 5, 2019·European Journal of Applied Physiology·Katarzyna Patrycja Dzik, Jan Jacek Kaczor
Feb 25, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Eduarda CerónNoé Alvarado-Vásquez
Sep 2, 2020·Journal of the American College of Nutrition·Navya VyasSonal Sekhar Miraj
Apr 11, 2020·Journal of the American College of Nutrition·Virginia M LindleySushil K Jain
Oct 13, 2020·Journal of the American College of Nutrition·Claudia I Gamboa-GómezLuis E Simental-Mendía
Feb 11, 2021·International Journal of Molecular Sciences·Antonio ManciniAndrea Silvestrini
Mar 4, 2021·Hormone Molecular Biology and Clinical Investigation·Karel Vondra, Richard Hampl
Mar 6, 2021·Journal of Endocrinological Investigation·G MazziottiUNKNOWN Humanitas COVID19 Task Force
Mar 8, 2021·BMC Nephrology·Colleen S Curran, Jeffrey B Kopp
Mar 17, 2021·European Journal of Pharmacology·Morry Silberstein
May 4, 2020·European Journal of Pharmacology·Luzia Kalyne Almeida Moreira LealGlauce Socorro de Barros Viana
Dec 2, 2020·Computers in Biology and Medicine·Pandikannan KrishnamoorthyHimanshu Kumar
Jul 13, 2021·Gene Reports·Falaque Ul AfshanBashir Ahmad Ganai
Aug 6, 2021·Nutrition·Danilo Társio Mota BritoRoberto de Barros Silva
Aug 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Bindu D PaulSolomon H Snyder
Sep 25, 2021·Protein Science : a Publication of the Protein Society·Mobeen AbdrabboSanchita Hati
Dec 11, 2021·Postgraduate Medicine·Victoria Contreras-BolívarManuel Muñoz-Torres

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Methods Mentioned

BETA
MDA
enzyme-linked immunosorbent assay
ELISA
blood drawn
transfection
electrophoresis
X-ray
Assay

Software Mentioned

Sigma Stat
ImageJ

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