Gluten Free Wheat: Are We There?

Nutrients
María Dolores García-MolinaFrancisco Barro

Abstract

Gluten proteins, major determinants of the bread-making quality of wheat, are related to several digestive disorders. Advances in plant genetic breeding have allowed the production of wheat lines with very low gliadin content through the use of RNAi and gene editing technologies. In this review, we carried out a comprehensive study of the application of these cutting-edge technologies towards the development of wheat lines devoid of immunogenic gluten, and their genetic, nutritional and clinical characterization. One line, named E82, showed outstanding nutritional properties, with very low immunogenic gluten and a low stimulation capacity of T-cells from celiac patients. Moreover, a clinical trial with non-celiac wheat sensitivity (NCWS) patients showed that the consumption of bread made with this E82 low gliadin line induced positive changes in the gut microbiota composition.

References

Jul 1, 1995·The Plant Cell·P R ShewryA S Tatham
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·K PalosuoT Reunala
Mar 26, 2002·Journal of Experimental Botany·Peter R Shewry, Nigel G Halford
Sep 5, 2002·Nature Reviews. Immunology·Ludvig M Sollid
Sep 28, 2002·Science·Lu ShanChaitan Khosla
Oct 31, 2002·Advances in Food and Nutrition Research·Peter R ShewryPeter S Belton
Apr 19, 2003·European Journal of Gastroenterology & Hepatology·Israel ValdésEnrique Méndez
Oct 29, 2003·Journal of Dermatological Science·E MoritaA S Tatham
Sep 11, 2004·Immunity·Sophie HüeSophie Caillat-Zucman
Sep 15, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Jocelyn A Silvester, Mohsin Rashid
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra CamarcaCarmen Gianfrani
Jul 24, 2010·Science Translational Medicine·Jason A Tye-DinRobert P Anderson
Sep 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Javier Gil-HumanesFrancisco Barro
Dec 21, 2010·Alimentary Pharmacology & Therapeutics·M MarinéM Esteve
May 13, 2011·Journal of Experimental Botany·Javier Gil-HumanesFrancisco Barro
Dec 14, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chelsea SnellAgnès E Ricroch
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Shanshan WenSachin Rustgi
Dec 5, 2012·The Journal of Experimental Medicine·Yvonne JunkerDetlef Schuppan
May 4, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cristina BucciCarolina Ciacci
Jan 16, 2014·Journal of Food Science and Technology·A S Bawa, K R Anilakumar
Nov 5, 2014·PloS One·Wilhelm Klümper, Matin Qaim
Jun 20, 2017·Journal of Proteomics·María Dolores García-MolinaFrancisco Barro
Jun 28, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Carmen Victoria Ozuna, Francisco Barro
Sep 19, 2017·Plant Biotechnology Journal·Susana Sánchez-LeónFrancisco Barro
Mar 20, 2018·Nature Biotechnology·Xiaosa LiJia Chen
Aug 22, 2018·Science Advances·Angéla JuhászOdd-Arne Olsen

❮ Previous
Next ❯

Citations

Oct 5, 2019·Plant Biotechnology Journal·Zhiyong ZhangJoachim Messing
May 27, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Dorota Mańkowska-Wierzbicka, Marta Stelmach-Mardas
Feb 6, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Daowen WangKunpu Zhang
Nov 12, 2020·Expert Review of Gastroenterology & Hepatology·Alma KurkiKatri Lindfors
Nov 22, 2020·Nature Reviews. Gastroenterology & Hepatology·Laura KiveläKatri Lindfors
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Sachin RustgiJan A Delcour
Aug 21, 2021·Artificial Intelligence in Medicine·Martín Pérez-PérezAnália Lourenço

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
ELISA
electrophoresis
infrared spectroscopy
targeted mutation

Software Mentioned

CODEX

Related Concepts

Related Feeds

CAR-T cells

Chimeric antigen receptor (CAR) T cells are cells that are genetically engineered to recognize and target specific proteins. The ability of these cells to recognize cancer antigens and eliminate tumor cells have transformed cancer immunotherapy approaches. Here is the latest research on CAR-T cells.

Related Papers

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Chongwei CuiGuha Krishnaswamy
Adolescent Medicine: State of the Art Reviews
Fotini Tania Mitsinikos, Michelle Pietzak
The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
Orhan Sezgin
Vnitr̆ní lékar̆ství
Pavel Kohout
© 2022 Meta ULC. All rights reserved