Gluten Intake and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in Children at Increased Risk of the Disease: The Diabetes Autoimmunity Study in the Young (DAISY).

Diabetes Care
Nicolai A Lund-BlixJill M Norris

Abstract

To study the association of gluten intake with development of islet autoimmunity and progression to type 1 diabetes. The Diabetes Autoimmunity Study in the Young (DAISY) follows children with an increased risk of type 1 diabetes. Blood samples were collected at 9, 15, and 24 months of age, and annually thereafter. Islet autoimmunity was defined by the appearance of at least one autoantibody against insulin, IA2, GAD, or ZnT8 (zinc transporter 8) in at least two consecutive blood samples. Using food frequency questionnaires, we estimated the gluten intake (in grams per day) annually from 1 year of age. Cox regression modeling early gluten intake, and joint modeling of the cumulative gluten intake during follow-up, were used to estimate hazard ratios adjusted for confounders (aHR). By August 2017, 1,916 subjects were included (median age at end of follow-up 13.5 years), islet autoimmunity had developed in 178 participants, and 56 of these progressed to type 1 diabetes. We found no association between islet autoimmunity and gluten intake at 1-2 years of age or during follow-up (aHR per 4 g/day increase in gluten intake 1.00, 95% CI 0.85-1.17 and 1.01, 0.99-1.02, respectively). We found similar null results for progression from isl...Continue Reading

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Citations

May 28, 2019·Journal of Diabetes·Swathi Sethuram, Robert Rapaport
Mar 13, 2020·Diabetes/metabolism Research and Reviews·Lauren K Wood HeickmanAlessio Fasano
Sep 27, 2019·Frontiers in Endocrinology·Susanna EspositoNicola Principi
May 18, 2020·Hormones : International Journal of Endocrinology and Metabolism·Anna KantaKalliopi Kotsa
Jan 12, 2021·Frontiers in Nutrition·Elvira VerduciAnnalisa Terranegra
Apr 20, 2021·Frontiers in Nutrition·Emma E Hamilton-WilliamsJessica L Dunne
Jul 25, 2021·International Journal of Molecular Sciences·Witold BauerAdam Krętowski
Jul 22, 2021·Minerva Pediatrics·Giulio FrontinoRiccardo Bonfanti

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