Gluten neuropathy: prevalence of neuropathic pain and the role of gluten-free diet

Journal of Neurology
Panagiotis ZisMarios Hadjivassiliou

Abstract

Peripheral neuropathy is a common extraintestinal manifestation of gluten sensitivity (gluten neuropathy). We aimed to establish the prevalence of neuropathic pain in patients with otherwise idiopathic PN and gluten sensitivity (positive antigliadin, endomysial, and/or transglutaminase antibodies, with or without enteropathy) and to describe any contributory factors. All consecutive patients with gluten neuropathy (GN) attending a specialist gluten/neurology clinic were invited to participate. Pain was assessed via the DN4 questionnaire and the visual analog scale. Overall Neuropathy Limitations Scale was used to assess the severity of neuropathy. The Mental Health Index (MHI-5) was used to measure participants' general mental health status. In total, 60 patients (76.7% males, mean age 69.9 ± 10.1 years) with GN were recruited. Neuropathic pain was present in 33 patients (55.0%). Comparison between groups of painful and not painful GN did not show significant differences regarding age, gender, neuropathy severity and neuropathy type. Patients with painless GN were more likely to be on a strict gluten-free diet (55.6 versus 21.2%, p = 0.006). Patients with painful GN presented with significantly worse MHI-5 score (75.9 ± 13.8 ve...Continue Reading

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Citations

Feb 15, 2019·Nutrients·Elizabeth S MearnsMarios Hadjivassiliou
Feb 27, 2019·Current Treatment Options in Neurology·Panagiotis Zis, Marios Hadjivassiliou
Jul 31, 2019·Postgraduate Medicine·Panagiotis ZisMarios Hadjivassiliou
Sep 10, 2019·JAMA Neurology·Anne Louise Oaklander, Maria Nolano
Aug 19, 2020·Advances in Therapy·Andreas LiampasPanagiotis Zis
May 19, 2019·Digestive Diseases and Sciences·Benjamin A LernerBenjamin Lebwohl
Jul 10, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Panagiotis ZisAntonella Paladini
Nov 24, 2018·Journal of Neurology·Thomas JulianPanagiotis Zis
Jun 30, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Ayesha GirachPanagiotis Zis
Aug 6, 2020·Journal of Neurology·Panagiotis ZisMarios Hadjivassiliou
Aug 23, 2020·Nutrients·Amanda C Fifi, Kathleen F Holton
Oct 12, 2018·Nutrients·Panagiotis ZisMarios Hadjivassiliou
Nov 5, 2020·Pain and Therapy·Andreas LiampasPanagiotis Zis
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Nov 16, 2021·Postgraduate Medicine·Andreas LiampasPanagiotis Zis
Dec 19, 2021·Journal of Medical Case Reports·S N BardakovB L Gavriluk

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