PMID: 16508226Mar 2, 2006Paper

Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia

Internal Medicine
Masafumi IharaShun Shimohama

Abstract

Gluten sensitivity is associated with multiple neurological abnormalities including gluten ataxia, motor neuron disease-like neuropathy, small fiber type neuropathy, cognitive impairment, and even parkinsonism. We investigated whether or not gluten sensitivity is involved in Japanese patients with idiopathic cerebellar ataxia with extracerebellar presentation. Fourteen patients with idiopathic cerebellar ataxia with extracerebellar presentation (autonomic instability, parkinsonism, or pyramidal dysfunction in varying combinations) were screened for anti-gliadin antibodies (AGA) to analyze for the presence or absence of gluten sensitivity. Patients with typical MR findings of multiple system atrophy of the cerebellar type were excluded. As disease controls without cerebellar ataxia, 9 patients with Parkinson's disease and 18 patients with amyotrophic lateral sclerosis were screened for AGA. Forty-seven normal controls were also screened for AGA. We found a high prevalence of AGA in 5 (36%) of 14 cerebellar ataxia patients, but in only 1 (4%) of 27 disease controls without cerebellar ataxia (odds ratio, 14.4; 95% CI, 1.41147; p<0.05) and in only 1 (2%) of 47 normal controls (odds ratio, 25.6; 95% CI, 2.66246; p<0.001). Among the ...Continue Reading

References

Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Oct 26, 1999·European Neurology·L LuostarinenP Collin
Jan 18, 2002·The New England Journal of Medicine·Richard J Farrell, Ciarán P Kelly
Apr 24, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M HadjivassiliouG A B Davies-Jones
May 3, 2002·Pediatrics·Linda S Book
Feb 5, 2003·Brain : a Journal of Neurology·Marios HadjivassiliouAelwyn Davies-Jones
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M HadjivassiliouR A Grünewald
Jan 14, 2004·Neurology·Khalafalla O BusharaChristopher M Gomez

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Citations

Mar 11, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mario HabekVesna V Brinar
Sep 13, 2008·The Cerebellum·Marios HadjivassiliouRichard A Grünewald
Feb 22, 2012·Gut·Jonas F LudvigssonCarolina Ciacci
May 16, 2009·Internal Medicine·Kazunori NanriKiyoshi Koizumi
Jul 7, 2014·The Cerebellum·Kazunori NanriHidehiro Mizusawa
Oct 27, 2015·International Journal of Molecular Sciences·Sonja W Scholz, Jose Bras
Jan 15, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B P C van de WarrenburgO Riess
Jul 21, 2017·Neurology·Marios HadjivassiliouNigel Hoggard
Jun 6, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Chi-Ying LinSheng-Han Kuo
May 5, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·José Fidel Baizabal-Carvallo, Joseph Jankovic
Jun 21, 2013·Alimentary Pharmacology & Therapeutics·J Y KangK Y Ho
Apr 9, 2017·Journal of Gastroenterology·Mai FukunagaYoshikazu Kinoshita
Feb 15, 2019·Nutrients·Elizabeth S MearnsMarios Hadjivassiliou
Nov 25, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Juliana J SchmidtSergio L Schmidt

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