Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity

Metabolism: Clinical and Experimental
Shao-Wen WengChia-Wei Liou

Abstract

The objective of the study was to o investigate the relationship of the Gly482Ser (G482S) polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha (PPARGC1A) gene and type 2 diabetes mellitus (T2DM), obesity, and oxidative status in Chinese adults. We enrolled 276 T2DM patients and 1049 nondiabetic subjects aged at least 35 years. The G482S variant was detected using polymerase chain reaction and restriction enzyme digestion. The levels of thiobarbituric acid reactive substance, an indicator of lipid peroxidation, were measured in plasma samples. The homeostasis model assessment-estimated insulin resistance (HOMA-IR) index was determined for nondiabetic subjects. P values were adjusted for age, sex, and body mass index by using a generalized linear model. In this series, there was no association between G482S polymorphism and T2DM and obesity (body mass index >25 kg/m(2)). However, the plasma fasting insulin levels and HOMA-IR indices were significantly higher in nondiabetic subjects harboring the variant (S/S) genotype than in those with the heterozygous (G/S) genotype. With regard to the effect of the different genotypes on body fat distribution, overweight nondiabetic subjects harboring the S/S...Continue Reading

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Citations

Feb 25, 2014·International Journal of Molecular Sciences·Azahara I RupérezConcepción M Aguilera
May 6, 2011·Journal of Neuroscience Research·Shan WangJin-Jing Pei
May 6, 2016·Frontiers in Cellular Neuroscience·Angelique PasquinelliGabriele Siciliano
Dec 1, 2017·Endocrinology·Roxanne VandenbeekJennifer L Estall
Jul 15, 2015·Journal of Bacteriology·Crystal M AustinRobert J Maier

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