Glyburide inhibits the bone resorption induced by traumatic occlusion in rats

Journal of Periodontal Research
Yoichi AritaRyuji Sakagami

Abstract

To examine whether glyburide inhibits bone destruction caused by traumatic occlusion in a rat occlusal trauma model. Excessive mechanical stress, such as traumatic occlusion, induces expression of IL-1β and may be involved in bone resorption. NLRP3 inflammasomes have been linked to IL-1β expression, but it is currently unclear whether glyburide, the inhibiter of NLRP3 inflammasome, suppresses occlusal trauma in rats. Male SD rats aged 7 weeks were used. In the trauma group, the occlusal surface of the maxillary first right molar was raised by attaching a metal wire to apply occlusal trauma to the mandibular first right molar. In the trauma + glyburide group, the NLRP3 inhibitor glyburide was administered orally every 24 hours from 1 day before induction of occlusal trauma. Rats were euthanized after 5 or 10 days, and the maxillary first molars were harvested with the adjacent tissues for histopathological investigation. Immunohistochemical expression of IL-1β, NLRP3, and RANKL was also assessed. On day 5, bone resorption was significantly greater in the trauma group compared with the control group or the trauma + glyburide group, and there were significantly higher numbers of osteoclasts and cells positive for IL-1β, NLRP3, and...Continue Reading

References

Mar 1, 1971·Journal of Dental Research·I Glickman
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H YasudaT Suda
Sep 9, 1998·The Journal of Experimental Medicine·K FullerT J Chambers
Jan 26, 1999·Annals of the New York Academy of Sciences·C A Dinarello
Mar 13, 2001·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·N AlhashimiM Bakhiet
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroyuki KanzakiHideo Mitani
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Matthew C Riddle
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jul 27, 2005·Journal of Endodontics·Xiaolei Zhang, Bin Peng
Oct 10, 2006·Vitamins and Hormones·Ichiro Nakamura, Eijiro Jimi
Mar 3, 2007·Gene·James H-C WangHee-Jeong Im
Mar 14, 2007·Molecular Cell·Benjamin FaustinJohn C Reed
Aug 19, 2008·European Journal of Oral Sciences·Cameron G WalkerThomas G H Diekwisch
Oct 7, 2009·The Journal of Cell Biology·Mohamed LamkanfiVishva M Dixit
Sep 13, 2011·Nature Medicine·Tomoki NakashimaHiroshi Takayanagi
Oct 25, 2011·Cytokine & Growth Factor Reviews·Gloria Lopez-Castejon, David Brough
Mar 21, 2012·Nature Immunology·Vijay A K RathinamKatherine A Fitzgerald
Jun 21, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Marc SimardVolodymyr Gerzanich
Oct 15, 2013·Journal of Clinical Periodontology·Gabriel A SánchezLucila Busch
Nov 29, 2013·American Journal of Physiology. Renal Physiology·Francis M HughesJ Todd Purves
Feb 6, 2015·Journal of Inflammation Research·Ema OzakiSarah L Doyle
Mar 24, 2015·PloS One·Simona GranataGianluigi Zaza
May 9, 2015·Mediators of Inflammation·Piero RuscittiRoberto Giacomelli

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Citations

Aug 8, 2020·Journal of Dental Research·E PapathanasiouT C Theoharides

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