Glycaemia and phosphatemia after oral glucose and maltitol ingestion in subjects from two different race groups: preliminary evidence of inter-race differences in metabolism and possible implications for urinary stone disease

International Urology and Nephrology
Takalani Theka, Allen Rodgers

Abstract

Glucose (Glu) and maltitol (Mal) ingestion affect calciuria and phosphaturia. Renal phosphate leak involving hypophosphatemia is thought to be a mechanism. Inter-race differences in carbohydrate metabolism are known. We investigated the effects of Glu and Mal ingestion on glycaemia and phosphatemia in subjects from two race groups to better understand potential implications for nephrolithiasis. Healthy black (B) (n = 8) and white (W) (n = 8) males followed a self-selected standardized diet for 7 days and a strictly controlled standardized diet on Day 8. After an overnight fast, subjects provided blood samples prior to and 30 min after ingestion of a randomly assigned solution of Glu or Mal. Blood Glu and serum phosphate were measured. Protocols were swapped after a 1-week washout period. Following Glu ingestion, glycaemia increased significantly in W (4.8 vs 6.2 mmol/l) but not in B (4.7 vs 5.3 mmol/l) while phosphatemia decreased significantly in B (1.16 vs 1.01 mmol/l) but not in W (1.24 vs 1.15 mmol/l). After Mal ingestion, glycaemia increased significantly in B (4.7 vs 5.2 mmol/l) but not in W (4.6 vs 5.9 mmol/l), while phosphatemia decreased significantly in W (1.24 vs 1.18 mmol/l) but not in B (1.17 vs 1.06 mmol/l). Our r...Continue Reading

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Citations

Jul 24, 2020·International Journal of Environmental Research and Public Health·Ariana SaraivaAntónio Raposo

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