Glycaemic instability is an underestimated problem in Type II diabetes

Clinical Science
Stephan F E PraetLuc J C van Loon

Abstract

The aim of the present study was to assess the level of glycaemic control by the measurement of 24 h blood glucose profiles and standard blood analyses under identical nutritional and physical activity conditions in patients with Type II diabetes and healthy normoglycaemic controls. A total of 11 male patients with Type II diabetes and 11 healthy matched controls participated in a 24 h CGMS (continuous subcutaneous glucose-monitoring system) assessment trial under strictly standardized dietary and physical activity conditions. In addition, fasting plasma glucose, insulin and HbA(1c) (glycated haemoglobin) concentrations were measured, and an OGTT (oral glucose tolerance test) was performed to calculate indices of whole-body insulin sensitivity, oral glucose tolerance and/or glycaemic control. In the healthy control group, hyperglycaemia (blood glucose concentration >10 mmol/l) was hardly present (2+/-1% or 0.4+/-0.2/24 h). However, in the patients with Type II diabetes, hyperglycaemia was experienced for as much as 55+/-7% of the time (13+/-2 h over 24 h) while using the same standardized diet. Breakfast-related hyperglycaemia contributed most (46+/-7%; P<0.01 as determined by ANOVA) to the total amount of hyperglycaemia and po...Continue Reading

References

Jul 1, 1990·Journal of Applied Physiology·R BursteinE Karnieli
Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Aug 28, 2001·Diabetes Care·K JungheimUNKNOWN Glucose Monitoring Study Group
Jan 30, 2002·Diabetes Care·Alberto MaranMaurizio Varalli
Jul 18, 2002·Cardiovascular Diabetology·Doron Aronson, Elliot J Rayfield
Aug 14, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S Del Prato
Sep 14, 2002·Annals of Clinical Biochemistry·Patrick Sharp, Sandra Rainbow
Sep 11, 2003·European Heart Journal·Guy De BackerUNKNOWN Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice
Jan 7, 2004·Diabetes & Metabolism·P Schaepelynck-BélicarV Lassmann-Vague
Jun 18, 2004·The American Journal of the Medical Sciences·Glen H MurataUNKNOWN Diabetes Outcomes in Veterans Study
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·S L Jeffcoate
Aug 13, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M Davies
Aug 26, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Anneloes KerssenGerard H A Visser
Apr 29, 2005·Diabetes Technology & Therapeutics·C M McDonnellF J Cameron

❮ Previous
Next ❯

Citations

Apr 14, 2007·Analytical and Bioanalytical Chemistry·Venkata Radhakrishna Kondepati, H Michael Heise
Jan 20, 2010·Clinical and Experimental Pharmacology & Physiology·Yu-Qian BaoWei-Ping Jia
May 30, 2009·Acta Diabetologica·Stephan F E Praet, Luc J C van Loon
Oct 28, 2011·Nutrition Reviews·Marika Leenders, Luc J C van Loon
Jul 4, 2012·Maturitas·Stephen R Bird, John A Hawley
Jul 16, 2010·Journal of Psychosomatic Research·Cynthia Fritschi, Laurie Quinn
Oct 3, 2009·Journal of the American Academy of Nurse Practitioners·Brian Lee Christensen, Mary Williams
Mar 4, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L HuneaultA Tremblay
Apr 19, 2011·Diabetes Research and Clinical Practice·Jan-Willem van DijkLuc J C van Loon
Mar 9, 2012·Diabetes Care·Jan-Willem van DijkLuc J C van Loon
Oct 5, 2016·Current Diabetes Reports·Paddy C DempseyDavid W Dunstan
Mar 10, 2018·Bulletin of Mathematical Biology·Minu R PilvankarAshlee N Ford Versypt
Aug 25, 2007·European Journal of Clinical Nutrition·R J F MandersL J C van Loon
Nov 21, 2009·Medicine and Science in Sports and Exercise·Ralph J F MandersLuc J C van Loon
Jul 28, 2007·Journal of Applied Physiology·Stephan F E Praet, Luc J C van Loon
Oct 2, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Haiyan LuJose Bernardo Quintos
May 20, 2017·Journal of Applied Physiology·Melissa L EricksonNathan T Jenkins
Nov 19, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Charlotte GredalJannik Hilsted
Mar 20, 2013·Medicine and Science in Sports and Exercise·Jan-Willem Van DijkLuc J C Van Loon
Sep 22, 2011·Diabetes Technology & Therapeutics·Lisa T Meade
Aug 10, 2017·Frontiers in Physiology·Monique E FrancoisJonathan P Little
Oct 5, 2017·Frontiers in Endocrinology·Melissa L EricksonKevin K McCully
Dec 17, 2020·Diagnostics·Andrés Herane-VivesJan Benöhr
Feb 27, 2015·Diabetes Spectrum : a Publication of the American Diabetes Association·Jan-Willem van Dijk, Luc J C van Loon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.