Glycaemic status during pregnancy and longitudinal measures of fetal growth in a multi-racial US population: a prospective cohort study.

The Lancet. Diabetes & Endocrinology
Mengying LiC Zhang

Abstract

The timepoint at which fetal growth begins to differ by maternal glycaemic status is not well understood. To address this lack of data, we examined gestational diabetes, impaired glucose tolerance, and early pregnancy glucose concentrations in relation to fetal growth trajectories. This cohort study included 2458 pregnant women from the NICHD Fetal Growth Studies-Singletons study, which took place between 2009 and 2013. Women were recruited from 12 clinical centres in the USA. Women aged 18-40 years without major chronic conditions when entering pregnancy were included and those with records of neither glucose screening test or glucose tolerance test were excluded from the study. Women were enrolled at gestational weeks 8-13 and randomly assigned to four ultrasonogram schedules (Group A; weeks 16, 24, 30, 34; Group B: weeks 18, 26, 31, 35, 39; Group C: weeks 20, 28, 32, 36; Group D: weeks 22, 29, 33, 37, 41) to capture weekly fetal growth. Gestational diabetes, impaired glucose tolerance, and normal glucose tolerance were defined by medical record review. Glucose was measured in a subsample of women at weeks 10-14. We modelled fetal growth trajectories using linear mixed models with cubic splines. This study is registered with ...Continue Reading

Associated Clinical Trials

Citations

May 27, 2020·The American Journal of Clinical Nutrition·Chittaranjan S Yajnik, Parag C Yajnik
Jun 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Marie MonlunVincent Rigalleau
Nov 21, 2020·BMJ Open Diabetes Research & Care·Yanfang GuoShi Wu Wen
Nov 7, 2020·Frontiers in Endocrinology·Julia Bandres-MerizGernot Desoye
Jul 20, 2021·Current Opinion in Pharmacology·Maria MirabelliAntonio Brunetti
Aug 11, 2021·JAMA : the Journal of the American Medical Association·Cuilin Zhang, Patrick Catalano
Nov 5, 2021·Current Diabetes Reports·Grenye O'MalleyCarol J Levy

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