Glycaemic variability and its association with enteral and parenteral nutrition in critically ill ventilated patients

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Ra'eesa DoolaDavid J Sturgess

Abstract

Extremes of dysglycaemia as well as glycaemic variability are associated with excess mortality in critically ill patients. Glycaemic variability is an increasingly important measure of glucose control in the intensive care unit (ICU) due to this association; however, there is limited data pertaining to the relationship between exogenous glucose from nutrition and glycaemic variability and clinical outcomes. The primary aim of this study was to determine if glycaemic variability is associated with an increase in mortality. Secondary objectives were to investigate any factors affecting glycaemic variability, and to characterise the role nutrition, particularly carbohydrate, plays as a contributing factor to glycaemic variability and other clinical outcomes (duration of ventilation and ICU length of stay). Data on patients in a combined medical/surgical tertiary Australian Intensive Care Unit (ICU), ventilated for >24 h and exclusively fed by artificial nutrition support was extracted from a clinical database of prospectively collected information over an 18 month period. Glycaemic variability was defined as the coefficient of variation (GV; standard deviation/mean of blood glucose levels x 100). Statistical analysis was performed...Continue Reading

Citations

Jun 18, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Igor EckertJussara C de Almeida
Dec 31, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Ra'eesa Doola, Jean-Charles Preiser

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