Glycaemic variability using continuous glucose monitoring and endothelial function in the metabolic syndrome and in Type 2 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
S BuscemiS Verga

Abstract

Subjects who are at increased risk of developing diabetes may have increased glycaemic variability associated with endothelial dysfunction and possibly subclinical atherosclerosis, which may lead to increased cardiovascular risk observed at the time of diabetes diagnosis. To investigate this hypothesis, we measured endothelial function, carotid intima-media thickness and glycaemic variability using 48-h continuous subcutaneous glucose monitoring in 3 groups of overweight or obese subjects--those without the metabolic syndrome, and those with the metabolic syndrome with or without newly diagnosed Type 2 diabetes. Consecutive subjects, aged 30-65 years with a body mass index >or= 25 kg/m(2) were recruited. Patients were classified as with or without the metabolic syndrome,or as metabolic syndrome with newly diagnosed Type 2 DM. Glycaemic variability was calculated in terms of the coefficient of variation. Endothelial function was measured using brachial artery flow-mediated dilation. We identified 75 subjects. Mean flow mediated dilation decreased (P < 0.001) and carotid intima-media thickness increased (P < 0.05) across groups. Flow mediated dilation predictors included mean 48-h continuous subcutaneous glucose monitoring values...Continue Reading

References

Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Jan 30, 2002·Diabetes Care·Alberto MaranMaurizio Varalli
Feb 1, 2002·Journal of Hypertension·Alain SimonJaime Levenson
Oct 5, 2002·Hypertension·Fernando A Prattichizzo, Fabio Galetta
Apr 29, 2004·American Journal of Physiology. Renal Physiology·T S PolhillC A Pollock
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Louis MonnierClaude Colette
Aug 5, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Kosuke AzumaHirotaka Watada
Oct 27, 2006·Diabetes Care·Boris P KovatchevWilliam Clarke
Feb 21, 2007·Hypertension·Ana BaracJulio A Panza
Mar 14, 2007·Circulation·John E DeanfieldTon J Rabelink
Sep 14, 2007·Clinical Pharmacology and Therapeutics·J A BatsisF Lopez-Jimenez
Sep 27, 2008·Acta Diabetologica·Silvio BuscemiGiovanni Cerasola
Mar 24, 2009·European Journal of Clinical Investigation·S BuscemiG Cerasola
Oct 10, 2009·Diabetes Research and Clinical Practice·Silvio BuscemiGiovanni Cerasola
Nov 4, 2009·Journal of Diabetes Science and Technology·Louis MonnierDavid R Owens
Dec 8, 2009·Endocrine Reviews·Sarah E SiegelaarJ Hans DeVries

❮ Previous
Next ❯

Citations

Feb 9, 2012·Diabetes Technology & Therapeutics·Alexia S PeñaPeter Baghurst
Nov 10, 2011·International Journal of Clinical Practice. Supplement·T Battelino, B W Bode
Jan 1, 2012·Nephron. Physiology·Guy M L PerryJohn R Asplin
Oct 3, 2012·PloS One·Akifumi OgawaMasayoshi Shichiri
Feb 1, 2014·Diabetes Technology & Therapeutics·Tadej Battelino, Bruce W Bode
Nov 1, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Silvio BuscemiGiovam Battista Rini
Sep 25, 2012·Heart Failure Clinics·Jared Moore, Kathleen Dungan
Oct 1, 2016·Journal of the Saudi Heart Association·Mona AdelLamia Kheder
Aug 1, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunsuke KataokaKazuo Kimura
Sep 4, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi Asanuma, Masafumi Kitakaze
Dec 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·B J Boucher
May 31, 2014·Journal of Diabetes Science and Technology·Oliver SchnellLouis Monnier
May 31, 2014·Journal of Diabetes Science and Technology·Sara J SalkindRobert A Vigersky
May 31, 2014·Journal of Diabetes Science and Technology·Oliver SchnellBruno Vergès
Oct 27, 2017·Diabetes, Obesity & Metabolism·Myfanwy C GeyerJennifer J Couper
Aug 1, 2015·The American Journal of Clinical Nutrition·Jeannie TayGrant D Brinkworth
Jul 22, 2018·Diabetes/metabolism Research and Reviews·Annunziata NuscaGermano Di Sciascio
Feb 21, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Denisa Janíčková ŽďárskáJan Brož
Mar 20, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jordan LoaderMatthieu Roustit
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Ilaria GiordaniSimona Frontoni
Apr 10, 2013·Journal of Diabetes Science and Technology·Oliver SchnellBruno Vergès
Mar 25, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Katherine A SauderCyril W C Kendall
May 7, 2020·International Journal of Hypertension·Xuenan PengYana Ma
May 17, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Yoichi HatamotoHiroaki Tanaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.