Glycans as critical regulators of gut immunity in homeostasis and disease

Cellular Immunology
Ana M DiasSalomé S Pinho

Abstract

The diversity of glycans expression within a cell or an organism is enormous and the amount of relevant biological information that each glycan structure encodes is far from being clarified. The importance of glycans in health and life sciences is highlighted by their multiple functional implications in different cellular and molecular biology processes with impact in homeostasis and diseases, such as cancer and inflammatory conditions. Glycans actively participate in the regulatory circuits that govern both innate and adaptive immune response. Changes in the glycans repertoire occur during the transition from normal to inflamed conditions and the aberrant expression of glycans dictates either pro-inflammatory or anti-inflammatory responses. This review summarizes how glycans integrate the regulatory networks of immune response with a focus on gut immunity.

References

Jan 29, 2020·Antioxidants & Redox Signaling·Irundika H K DiasHelen R Griffiths
Oct 1, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Tomás CerdóCristina Campoy

Related Concepts

Immune Response
Organism
Structure
Adaptive Immune Response
Molecular Biology
Humoral Immune Response
Malignant Neoplasms
Gut
Gene Circuits
Polysaccharides

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