Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody Production.

Frontiers in Molecular Biosciences
Xiaohui ZhaoHongliang Wang

Abstract

Viral protein glycosylation represents a successful strategy employed by the parasite to take advantage of host-cell machinery for modification of its own proteins. The resulting glycans have unneglectable roles in viral infection and immune response. The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which presents on the surface of matured virion and mediates viral entry into the host, also undergoes extensive glycosylation to shield it from the human defense system. It is believed that the ongoing COVID-19 pandemic with more than 90,000,000 infections and 1,900,000 deaths is partly due to its successful glycosylation strategy. On the other hand, while glycan patches on S protein have been reported to shield the host immune response by masking "nonself" viral peptides with "self-glycans," the epitopes are also important in eliciting neutralizing antibodies. In this review, we will summarize the roles of S protein glycans in mediating virus-receptor interactions, and in antibody production, as well as indications for vaccine development.

References

Jun 26, 2010·Nature Reviews. Immunology·Barry T Rouse, Sharvan Sehrawat
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Guiqing PengFang Li
Oct 24, 2012·The Journal of Biological Chemistry·Guiqing PengFang Li
Nov 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hugo MouquetPamela J Bjorkman
May 28, 2013·Nature Structural & Molecular Biology·Marie PanceraPeter D Kwong
Jun 12, 2013·Cold Spring Harbor Perspectives in Biology·Jörg Breitling, Markus Aebi
Nov 16, 2013·Nature Chemical Biology·Margreet A Wolfert, Geert-Jan Boons
Sep 29, 2015·The FEBS Journal·Katie J Doores
Mar 5, 2016·Nature·Robert N KirchdoerferAndrew B Ward
Apr 27, 2016·Cell·Guillaume B E Stewart-JonesPeter D Kwong
Sep 1, 2016·Annual Review of Virology·Fang Li
Oct 30, 2016·Current Opinion in Structural Biology·Rahul RamanRam Sasisekharan
Nov 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Preeyam Patel, John F Kearney
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jesper PallesenJason S McLellan
Sep 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Wentao LiBerend-Jan Bosch
Mar 27, 2018·Glycobiology·Ieva Bagdonaite, Hans H Wandall
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
May 24, 2019·Biochimica Et Biophysica Acta. General Subjects·Yasunori WatanabeMax Crispin
May 31, 2019·Nature·Amelia EscolanoMichel C Nussenzweig
Jun 5, 2019·Nature Structural & Molecular Biology·M Alejandra TortoriciDavid Veesler
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Jun 1, 2018·Future Virology·To Sing Fung, Ding Xiang Liu
Mar 27, 2020·Frontiers in Cellular and Infection Microbiology·Muhammed IraqiAngel Porgador
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
Apr 16, 2020·Turkish Journal of Medical Sciences·Mustafa HasöksüzFahriye Saraç
May 6, 2020·Science·Yasunori WatanabeMax Crispin
May 13, 2020·Annual Review of Virology·Melanie KoehlerDavid Alsteens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

© 2021 Meta ULC. All rights reserved